The role of homocysteine, asymmetric dimethylarginine and nitric oxide in pre-eclampsia

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dc.contributor.authorDemir, B.
dc.contributor.authorDemir, S.
dc.contributor.authorPasa, S.
dc.contributor.authorGuven, S.
dc.contributor.authorAtamer, Y.
dc.contributor.authorAtamer, A.
dc.contributor.authorKocyigit, Y.
dc.date.accessioned2024-04-24T17:20:26Z
dc.date.available2024-04-24T17:20:26Z
dc.date.issued2012
dc.departmentDicle Üniversitesien_US
dc.description.abstractNitric oxide (NO) contributes to vasodilatation that is observed during normal pregnancy. Hyperhomocysteinaemia (HHcy) is a vascular risk factor associated with placental microvascular diseases and pre-eclampsia. Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of endothelial nitric oxide synthase (NOS) has been linked to endothelial dysfunction. Maternal ADMA has been reported to be higher in women with pre-eclampsia and HHcy leads to accumulation of ADMA. The aim of this presented study is to evaluate the alterations of plasma homocysteine, ADMA and NO levels in mild pre-eclampsia. A total of 40 pre-eclamptic women and 40 healthy controls were included into the study. Mean systolic and diastolic blood pressure, mean serum homocysteine and ADMA levels were significantly higher and NO level was lower in patients. Serum homocysteine, ADMA and NO levels found to be correlated among them and with blood pressure. In conclusion, we found that homocysteine and ADMA levels were increased and NO levels decreased in pre-eclampsia.en_US
dc.identifier.doi10.3109/01443615.2012.693985
dc.identifier.endpage528en_US
dc.identifier.issn0144-3615
dc.identifier.issn1364-6893
dc.identifier.issue6en_US
dc.identifier.pmid22779953
dc.identifier.scopus2-s2.0-84863748497
dc.identifier.scopusqualityQ3
dc.identifier.startpage525en_US
dc.identifier.urihttps://doi.org/10.3109/01443615.2012.693985
dc.identifier.urihttps://hdl.handle.net/11468/19047
dc.identifier.volume32en_US
dc.identifier.wosWOS:000306234200005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofJournal of Obstetrics and Gynaecology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAsymmetric Dimethylarginineen_US
dc.subjectEndothelial Dysfunctionen_US
dc.subjectHomocysteineen_US
dc.subjectNitric Oxideen_US
dc.subjectPre-Eclampsiaen_US
dc.titleThe role of homocysteine, asymmetric dimethylarginine and nitric oxide in pre-eclampsiaen_US
dc.titleThe role of homocysteine, asymmetric dimethylarginine and nitric oxide in pre-eclampsia
dc.typeArticleen_US

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