A new alternative treatment in COPD: phosphodiesterase-4 inhibitors

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dc.contributor.authorSezgi, Cengizhan
dc.contributor.authorSenyigit, Abdurrahman
dc.date.accessioned2024-04-24T17:27:54Z
dc.date.available2024-04-24T17:27:54Z
dc.date.issued2011
dc.departmentDicle Üniversitesien_US
dc.description.abstractChronic obstructive pulmonary disease (COPD) is a disease which is characterized with progressive airflow obstruction and abnormal inflammatory response caused by noxious gases and particles. Recently oral phosphodiesterase-4 (PDE-4) inhibitors which block activation of inflammatory cells, are experimented as a new approach. Last studies showed that these drugs improve symptoms, pulmonary functions and quality of life, reduce the numbers of acute attacks, suppress bronchial inflammation in COPD. However these drugs lead to adverse reactions such as vomiting, diarrhea and headache. In this review we discussed roflumilast (Daxas) which was accepted by Food and Drug Administration (FDA), included in treatment of sever COPD in The Global Initiative for Chronic Obstructive Lung Disease (GOLD) guideline.en_US
dc.identifier.doi10.5578/tt.2460
dc.identifier.endpage290en_US
dc.identifier.issn0494-1373
dc.identifier.issue3en_US
dc.identifier.pmid22087527
dc.identifier.scopus2-s2.0-81855216374
dc.identifier.scopusqualityQ3
dc.identifier.startpage285en_US
dc.identifier.urihttps://doi.org/10.5578/tt.2460
dc.identifier.urihttps://hdl.handle.net/11468/20249
dc.identifier.volume59en_US
dc.identifier.wosWOS:000421294200012
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isotren_US
dc.publisherTurkish Assoc Tuberculosis & Thoraxen_US
dc.relation.ispartofTuberkuloz Ve Torak-Tuberculosis and Thorax
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCopden_US
dc.subjectInflammationen_US
dc.subjectPhosphodiesterase-4 Inhibitorsen_US
dc.titleA new alternative treatment in COPD: phosphodiesterase-4 inhibitorsen_US
dc.titleA new alternative treatment in COPD: phosphodiesterase-4 inhibitors
dc.typeReview Articleen_US

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