Systemic and local zoledronic acid treatment with hydroxyapatite bone graft: A histological and histomorphometric experimental study

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dc.contributor.authorGunes, Nedim
dc.contributor.authorDundar, Serkan
dc.contributor.authorSaybak, Arif
dc.contributor.authorArtas, Gokhan
dc.contributor.authorAcikan, Izzet
dc.contributor.authorOzercan, I. Hanifi
dc.contributor.authorAtilgan, Serhat
dc.date.accessioned2024-04-24T17:21:00Z
dc.date.available2024-04-24T17:21:00Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractIn this study, the aim was to compare the relative efficacy of systemic and local zoledronic acid (ZA) on a hydroxyapatite (HA) bone graft in a rat critical-size calvarial bone defect. In total, 84 female rats were divided into four groups: Empty control (EC) group with no treatment applied; HA group, in which only HA bone graft material was used in the calvarium; and HA plus local ZA (HA+LZA) and HA plus systemic ZA (HA+SZA) groups, in which animals received ZA locally or systemically, respectively, with HA bone graft material in the calvarium. A 5-mm standardised critical-size calvarial bone defect was created with a standard trephine drill and the respective treatment was applied. Rats were sacrificed 7, 14 and 28 days later. The numbers of osteoclasts and osteoblasts, and degree of bone formation were evaluated histopathologically and histomorphometrically. Statistically significant differences were detected between the HA, HA+LZA and HA+SZA groups and the EC group for new bone formation (P<0.05). Osteoblast numbers in the HA+LZA and HA+SZA groups were significantly higher compared with those in the EC and HA groups (P<0.05). No statistically significant difference was detected between the HA+LZA and HA+SZA groups in new bone formation or osteoblast number (P>0.05). Bone formation was significantly higher in the HA group than in the EC group (P<0.05). The numbers of osteoclasts in the HA+LZA and HA+SZA groups were significantly higher than those in the groups EC and HA (P<0.05); however, there was no significant difference between groups HA+LZA and HA+SZA (P>0.05). Within the limitations of this study, systemic or local administration of ZA enhanced new bone formation with a HA bone graft in a rat critical-size calvarial defect model.en_US
dc.identifier.doi10.3892/etm.2016.3685
dc.identifier.endpage2422en_US
dc.identifier.issn1792-0981
dc.identifier.issn1792-1015
dc.identifier.issue4en_US
dc.identifier.pmid27698743
dc.identifier.scopus2-s2.0-84987945001
dc.identifier.scopusqualityN/A
dc.identifier.startpage2417en_US
dc.identifier.urihttps://doi.org/10.3892/etm.2016.3685
dc.identifier.urihttps://hdl.handle.net/11468/19334
dc.identifier.volume12en_US
dc.identifier.wosWOS:000385578200075
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpandidos Publ Ltden_US
dc.relation.ispartofExperimental and Therapeutic Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHydroxyapatite Bone Graften_US
dc.subjectZoledronic Aciden_US
dc.subjectRat Calvariumen_US
dc.subjectCritical-Sized Defecten_US
dc.titleSystemic and local zoledronic acid treatment with hydroxyapatite bone graft: A histological and histomorphometric experimental studyen_US
dc.titleSystemic and local zoledronic acid treatment with hydroxyapatite bone graft: A histological and histomorphometric experimental study
dc.typeArticleen_US

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