Effects of antineoplastic agents on the peripheral nerves under a surgical tissue expansion procedure: An experimental study

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dc.contributor.authorOktay, M. Faruk
dc.contributor.authorAşkar, İbrahim
dc.contributor.authorYıldırım, Ayşe
dc.contributor.authorGürlek, Ali
dc.contributor.authorAkkuş, Murat
dc.contributor.authorTopçu, İsmail
dc.contributor.authorMeriç, Faruk
dc.contributor.orcid0000-0001-5708-4813
dc.date.accessioned2024-04-24T15:59:29Z
dc.date.available2024-04-24T15:59:29Z
dc.date.issued2006
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kulak, Burun ve Boğaz Hastalıkları Ana Bilim Dalıen_US
dc.description.abstractBackground. Elongation of peripheral nerve by the use of a tissue expander is helpful to repair nerve defects. This study was designed to investigate the effects of some antineoplastic agents on the peripheral nerves under a surgical tissue expansion procedure. Materials and Methods. Twenty-five Wistar rats were used in this study. Following the exposition of the sciatic nerve and placement of two 10/0-nylon sutures in the epineurium 20 mm apart, a tissue expander was then placed under it. Inflation of the expander was immediately accomplished by the separate percutaneous injections of 6, 6, and 8 ml for every 3 min under general anesthesia. The expander was fully deflated at the end of each 3 min The distance between two sutures was measured 1 h later to measure the rate of elongation. Rats were randomly divided into five groups (according to the administered drugs), each consisting of five rats (10 sciatic nerves). Normal saline (1 ml) in the control group (group 1), cyclophosphamide (15 mg/kg) in the group II, cisplatinum (3 mu g/kg) in the group III, mitomycin-C (0.5 mg/kg) in the group IV and 5-fluorouracil (10 mg/kg) in the group V were injected intravenously. Intravenous injections of drugs were performed via the tail vein 30 min before expansion, 48 and 96 h after removal of expander. The incision was reopened on the third and seventh postoperative days, and five sciatic nerves of each group were exposed and then the pinching test was performed to measure regeneration distance. Electro-neurographic changes were recorded. The expanded portion of the sciatic nerve between two sutures was harvested for histological evaluation. Results. There is no significant difference between the elongation rates of all groups (P < 0.05). Histologic evaluation showed that inflammatory changes, vacuolization, intraneural edema, demyelination, axonal changes in the control group, the cisplatinum group and the mitomycin-C group. These changes were significantly decreased in the cyclophosphamide group and the 5-fluorouracil group. In the cyclophosphamide group and the 5-fluorouracil group, the amplitude of compound action potential (CAP) values were significantly higher and the latency was significantly shorter (P > 0.05). Conclusion. We believed that cyclophosphamide and 5-fluorouracil may be helpful in tissue expansion of peripheral nerves, by decreasing the effects of the ischemia-reperfusion injury on the expanded peripheral nerves.en_US
dc.identifier.citationOktay, M. F., Aşkar, İ., Yıldırım, A., Gürlek, A., Akkuş, M., Topçu, İ. ve diğerleri. (2006). Effects of antineoplastic agents on the peripheral nerves under a surgical tissue expansion procedure: An experimental study. Microsurgery, 26(6), 473-479.
dc.identifier.doi10.1002/micr.20273
dc.identifier.endpage479en_US
dc.identifier.issn0738-1085
dc.identifier.issn1098-2752
dc.identifier.issue6en_US
dc.identifier.pmid16937332
dc.identifier.scopus2-s2.0-33749236784
dc.identifier.scopusqualityQ2
dc.identifier.startpage473en_US
dc.identifier.urihttps://doi.org/10.1002/micr.20273
dc.identifier.urihttps://hdl.handle.net/11468/14095
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/10.1002/micr.20273
dc.identifier.volume26en_US
dc.identifier.wosWOS:000240694000010
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorOktay, M. Faruk
dc.institutionauthorAşkar, İbrahim
dc.institutionauthorYıldırım, Ayşe
dc.institutionauthorAkkuş, Murat
dc.institutionauthorTopçu, İsmail
dc.institutionauthorMeriç, Faruk
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofMicrosurgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[No Keyword]en_US
dc.titleEffects of antineoplastic agents on the peripheral nerves under a surgical tissue expansion procedure: An experimental studyen_US
dc.titleEffects of antineoplastic agents on the peripheral nerves under a surgical tissue expansion procedure: An experimental study
dc.typeArticleen_US

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