Prognostic significance of pretreatment serum lactate dehydrogenase-to-albumin ratio in gastric cancer

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dc.authorid0000-0002-3161-0923en_US
dc.authorid0000-0002-9178-7843en_US
dc.contributor.authorAday, Ulaş
dc.contributor.authorTatlı, Faruk
dc.contributor.authorAkpulat, Faik V.
dc.contributor.authorİnan, Mazlum
dc.contributor.authorKafadar, Mehmet Tolga
dc.contributor.authorBilge, Hüseyin
dc.contributor.authorBaşol, Ömer
dc.contributor.authorOǧuz, Abdullah
dc.date.accessioned2021-07-30T05:55:01Z
dc.date.available2021-07-30T05:55:01Z
dc.date.issued2020en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Genel Cerrahi Ana Bilim Dalıen_US
dc.descriptionWOS:000615631000001
dc.descriptionPMID: 33235539
dc.description.abstractAim of the study: To investigate the prognostic role of lactate dehydrogenase-to-albumin ratio (LAR) in gastric cancer patients undergoing curative resection. Material and methods: A retrospective study was conducted including resectable gastric cancer patients. According to the time-dependent receiver operating characteristics (ROC) analysis, the optimal threshold for pretreatment LAR was 5.5. The Kaplan-Meier method, Cox regression univariate and multivariate analyses were used to analyze the prognostic factors for disease-free survival and overall survival (OS). Results: The study cohort consisted of 81 patients, mean age was 60.2 ±13.8 (range, 29-87) years and 55 (67.9%) were male. The median OS time was 34.8 and 45 months in patients with LAR ≥ 5.5 (n = 50) and LAR < 5.5 (n = 31), respectively. Kaplan-Meier curves showed that with the increase in LAR there was reduced survival, but it was not statistically significant (p = 0.278). Multivariate analyses revealed that the positive lymph node ratio above 20% was an independent predictor in resectable gastric cancer patients (OR = 6.281, 95% CI: 1.135-34.767, p = 0.035). Conclusions: With the increase in LAR survival in gastric cancer decreased, but it was not statistically significant. Studies involving a large patient series are needed.en_US
dc.identifier.citationAday, U., Tatlı, F., Akpulat, F. V., İnan, M., Kafadar, M. T., Bilge, H. ve diğerleri. (2020). Prognostic significance of pretreatment serum lactate dehydrogenase-to-albumin ratio in gastric cancer. Wspolczesna Onkologia, 24(3), 145-149.en_US
dc.identifier.doi10.5114/wo.2020.100219
dc.identifier.endpage149en_US
dc.identifier.issn1428-2526
dc.identifier.issue3en_US
dc.identifier.pmid33235539
dc.identifier.scopus2-s2.0-85095875181
dc.identifier.scopusqualityQ2
dc.identifier.startpage145en_US
dc.identifier.urihttps://www.termedia.pl/Prognostic-significance-of-pretreatment-serum-lactate-dehydrogenase-to-albumin-ratio-in-gastric-cancer,3,42181,0,1.html
dc.identifier.urihttps://hdl.handle.net/11468/7256
dc.identifier.volume24en_US
dc.identifier.wosWOS:000615631000001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAday, Ulaş
dc.institutionauthorTatlı, Faruk
dc.institutionauthorAkpulat, Faik V.
dc.institutionauthorİnan, Mazlum
dc.institutionauthorKafadar, Mehmet Tolga
dc.institutionauthorBilge, Hüseyin
dc.institutionauthorBaşol, Ömer
dc.institutionauthorOǧuz, Abdullah
dc.language.isoenen_US
dc.publisherTermedia Publishing House Ltd.en_US
dc.relation.ispartofWspolczesna Onkologia
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCurative surgeryen_US
dc.subjectGastric canceren_US
dc.subjectLARen_US
dc.subjectSurvivalen_US
dc.titlePrognostic significance of pretreatment serum lactate dehydrogenase-to-albumin ratio in gastric canceren_US
dc.titlePrognostic significance of pretreatment serum lactate dehydrogenase-to-albumin ratio in gastric cancer
dc.typeArticleen_US

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