The effects of intravenous immunoglobulin on cerebral ischemia in rats: An experimental study

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dc.contributor.authorTunik, Selcuk
dc.contributor.authorAluclu, Mehmet Ufuk
dc.contributor.authorAcar, Abdullah
dc.contributor.authorAkkoc, Hasan
dc.contributor.authorGuzel, Aslan
dc.contributor.authorAlabalik, Ulas
dc.contributor.authorAkkus, Murat
dc.date.accessioned2024-04-24T17:14:36Z
dc.date.available2024-04-24T17:14:36Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractStroke is one of the major reasons of death in the United States and related to adult disability. Despite aggressive research, the treatment approaches of stroke still remains a major clinical problem. Intravenous immunoglobulin (IVIg) is a polyspecific Ig G preparation obtained from plasma of several thousand healthy people (donors). IVIg is an important treatment approach and used for several disorders. The aim of this study was to investigate the potentially beneficial effects of IVIg therapy in experimentally induced ischemia in middle cerebral artery occlusion (MCAo) models of rats. A total of 30 adult male Sprague Dawley rats were used. The rats were divided into two equal groups, each consisting of 15 randomly selected rats: control group (n = 15) and IVIg group (n = 15). Intraluminal filament method was used for establishment of cerebral ischemia. Intraluminal filament was withdrawn after 2 h of MCAo and reperfusion started again and passed to therapeutic stages for all the groups. Physiologic saline solution of 0.5 ml/kg was administered to the control group and 400 mg/kg IVIg was given to the IVIg group rats intravenously. In neurological evaluation, the worst score was determined as 3 and the best score as 0. After routine process, the brain tissue was prepared histopathological investigation. The IVIg group showed significantly better recovery with respect to the control group by neurological examination. The observation of specimens obtained from IVIg groups showed that findings correlate with grade 1 and -2 histopathologically. Nevertheless, ischemic amendments were observed to comply with grade 3 in ischemic areas in control group. IVIg therapy can be used in the treatment of ischemic stroke patients.en_US
dc.identifier.doi10.1177/0748233713498461
dc.identifier.endpage234en_US
dc.identifier.issn0748-2337
dc.identifier.issn1477-0393
dc.identifier.issue2en_US
dc.identifier.pmid24081638
dc.identifier.scopus2-s2.0-84956762258
dc.identifier.scopusqualityQ2
dc.identifier.startpage229en_US
dc.identifier.urihttps://doi.org/10.1177/0748233713498461
dc.identifier.urihttps://hdl.handle.net/11468/18083
dc.identifier.volume32en_US
dc.identifier.wosWOS:000369179000005
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofToxicology and Industrial Health
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIschemiaen_US
dc.subjectIvigen_US
dc.subjectHistopathologyen_US
dc.subjectMcaoen_US
dc.titleThe effects of intravenous immunoglobulin on cerebral ischemia in rats: An experimental studyen_US
dc.titleThe effects of intravenous immunoglobulin on cerebral ischemia in rats: An experimental study
dc.typeArticleen_US

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