Impact of caffeic acid phenethyl ester treatment on vancomycin-induced pancreatic damage in rats

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dc.contributor.authorKoyu, Ahmet
dc.contributor.authorGokalp, Osman
dc.contributor.authorGumral, Nurhan
dc.contributor.authorOktem, Faruk
dc.contributor.authorKarahan, Nermin
dc.contributor.authorYilmaz, Nigar
dc.contributor.authorSaygin, Mustafa
dc.date.accessioned2024-04-24T17:14:36Z
dc.date.available2024-04-24T17:14:36Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractThis study investigates the preventive effect of caffeic acid phenethyl ester (CAPE) on pancreatic damage induced by vancomycin (VCM) in rats. Rats were equally divided into three groups: group I (control), group II (only VCM-treated group) and group III (VCM + CAPE-treated groups). VCM was intraperitoneally administered at a dose of 200 mg kg(-1) twice daily for 7 days. CAPE was administered orally at 10 mu M mL(-1) kg(-1) dose once daily for 7 days. The first dose of CAPE administration was performed 24 h prior to VCM injection. Blood and pancreas tissue samples were removed and collected after the study. Serum alkaline phosphatase (ALP), amylase, g-glutamyl transferase (GGT) and lipase activities were determined. Pancreas tissue samples were evaluated with the light microscope. Group II significantly increased serum ALP, amylase, GGT and lipase activities when compared with the control group. Group III significantly decreased serum ALP, amylase, GGT and lipase activities when compared with group II. In histopathological examination, it has been observed that there was a significant pancreatic damage in group II. CAPE exerted prominent structural protection against VCM-induced pancreatic damage and this effect was statistically significant. CAPE caused a marked reduction in the extent of pancreatic damage. We have concluded that it may play an important role in the VCM-induced pancreatic damage and reduce the pancreatic damage both at the biochemical and histopathological aspects.en_US
dc.identifier.doi10.1177/0748233713501708
dc.identifier.endpage312en_US
dc.identifier.issn0748-2337
dc.identifier.issn1477-0393
dc.identifier.issue2en_US
dc.identifier.pmid24097368
dc.identifier.scopus2-s2.0-84956824031
dc.identifier.scopusqualityQ2
dc.identifier.startpage306en_US
dc.identifier.urihttps://doi.org/10.1177/0748233713501708
dc.identifier.urihttps://hdl.handle.net/11468/18084
dc.identifier.volume32en_US
dc.identifier.wosWOS:000369179000015
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofToxicology and Industrial Health
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectVancomycinen_US
dc.subjectCaffeic Acid Phenethyl Esteren_US
dc.subjectPancreatic Histopathologyen_US
dc.subjectAmylaseen_US
dc.subjectLipaseen_US
dc.titleImpact of caffeic acid phenethyl ester treatment on vancomycin-induced pancreatic damage in ratsen_US
dc.titleImpact of caffeic acid phenethyl ester treatment on vancomycin-induced pancreatic damage in rats
dc.typeArticleen_US

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