Can clomiphene citrate resistance be predicted by RDW-CV levels in infertile women with PCOS?

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dc.contributor.authorPeker, Nurullah
dc.contributor.authorEge, Serhat
dc.contributor.authorBademkiran, Muhammet Hanifi
dc.contributor.authorAydin, Edip
dc.contributor.authorKaracor, Talip
dc.contributor.authorObut, Mehmet
dc.contributor.authorArac, Esref
dc.date.accessioned2024-04-24T17:24:17Z
dc.date.available2024-04-24T17:24:17Z
dc.date.issued2019
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: To identify whether red blood cell distribution width coefficient of variation (RDW-CV) and mean platelet volume (MPV) levels can predict clomiphene citrate resistance (CC-R) in infertile, anovulatory females with polycystic ovarian syndrome (PCOS). Methods: A total of 89 infertile patients who were admitted to a tertiary center diagnosed with non-obese PCOS were included in this study. The patients were divided into two groups: the first group comprised 53 non-obese patients with PCOS and CC-R, and the second group included 36 non-obese patients with PCOS and CC-S. RDW-CV, RDW-SD, and MPV values, along with routine whole blood count parameters were compared between the groups. Results: RDW-CV values were found to be significantly higher in the patients with CC-R compared to those with CC-S (P < 0.05). The sensitivity, specificity, positive, and negative predictive values were found to be 69%, 58.1%, 34.5%, and 12.5%, respectively, at an RDW-CV level of 12.85. The odds ratio was calculated as 3.077 (95% CI 1.245-7.603) in terms of the cut-off point. Conclusion: We think that RDW-CV which is a marker of inflammation is a simple, cheap, and accessible marker for the prediction of CC resistance.en_US
dc.identifier.doi10.4103/njcp.njcp_666_18
dc.identifier.endpage1466en_US
dc.identifier.issn1119-3077
dc.identifier.issue11en_US
dc.identifier.pmid31719265
dc.identifier.scopus2-s2.0-85074902064
dc.identifier.scopusqualityQ2
dc.identifier.startpage1463en_US
dc.identifier.urihttps://doi.org/10.4103/njcp.njcp_666_18
dc.identifier.urihttps://hdl.handle.net/11468/19582
dc.identifier.volume22en_US
dc.identifier.wosWOS:000502072400001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofNigerian Journal of Clinical Practice
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectClomiphene Citrate Resistanceen_US
dc.subjectInflammationen_US
dc.subjectPolycystic Ovarian Syndromeen_US
dc.subjectRed Blood Cell Distribution Widthen_US
dc.titleCan clomiphene citrate resistance be predicted by RDW-CV levels in infertile women with PCOS?en_US
dc.titleCan clomiphene citrate resistance be predicted by RDW-CV levels in infertile women with PCOS?
dc.typeArticleen_US

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