Serum prolidase enzyme activity and oxidative status in patients with Behçet's disease

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dc.authorid0000-0001-9740-5407en_US
dc.authorid0000-0002-5845-0851en_US
dc.contributor.authorBozkurt, Mehtap
dc.contributor.authorYüksel, Hatice
dc.contributor.authorEm, Serda
dc.contributor.authorOktayoğlu, Pelin
dc.contributor.authorYıldız, Mehmet
dc.contributor.authorAkdeniz, Dicle
dc.contributor.authorNas, Kemal
dc.date.accessioned2023-10-19T11:27:00Z
dc.date.available2023-10-19T11:27:00Z
dc.date.issued2014en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Fizik Tedavi ve Rehabilitasyon Ana Bilim Dalıen_US
dc.description.abstractObjectives: To assess serum prolidase enzyme activity and oxidative stress in patients with Behçet's disease (BD). Methods: The study population consisted of BD patients (n = 42) and healthy participants (n = 29). BD patients were classified as active (n = 18) or inactive (n = 24) according to disease activity. Serum prolidase enzyme activity, total antioxidant status (TAS), total oxidative status (TOS), oxidative stress index (OSI), and malondialdehyde (MDA) levels were measured. Results: In BD patients with active disease, serum prolidase activity was significantly higher compared with the inactive and control participants. Serum prolidase activity was also significantly higher in all BD patients in comparison with controls. Serum prolidase activity was also positively correlated with OSI, C-reactive protein, and active BD. MDA, TOS, and OSI levels were all significantly higher in the BD group when compared with the healthy control participants. Serum TAS levels were significantly lower in BD patients in comparison with healthy controls. Conclusion: High prolidase activity may indicate critical biological activities relevant to pathological events in BD, and this activity may be a biological indicator of disease. Further studies are needed to verify these findings.en_US
dc.identifier.citationBozkurt, M., Yüksel, H., Em, S., Oktayoğlu, P., Yıldız, M., Akdeniz, D. ve diğerleri. (2014). Serum prolidase enzyme activity and oxidative status in patients with Behçet's disease. Redox Report, 19(2), 59-64.en_US
dc.identifier.doi10.1179/1351000213Y.0000000072
dc.identifier.endpage64en_US
dc.identifier.issn1743-2928
dc.identifier.issue2en_US
dc.identifier.pmid24225260
dc.identifier.scopus2-s2.0-84894316198
dc.identifier.scopusqualityQ2
dc.identifier.startpage59en_US
dc.identifier.urihttps://www.tandfonline.com/doi/epdf/10.1179/1351000213Y.0000000072?needAccess=true
dc.identifier.urihttps://hdl.handle.net/11468/12885
dc.identifier.volume19en_US
dc.identifier.wosWOS:000337129800002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBozkurt, Mehtap
dc.institutionauthorYüksel, Hatice
dc.institutionauthorEm, Serda
dc.institutionauthorOktayoğlu, Pelin
dc.institutionauthorYıldız, Mehmet
dc.institutionauthorAkdeniz, Dicle
dc.institutionauthorNas, Kemal
dc.language.isoenen_US
dc.publisherTaylor and Francisen_US
dc.relation.ispartofRedox Report
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBehçet diseaseen_US
dc.subjectOxidative statusen_US
dc.subjectProlidaseen_US
dc.titleSerum prolidase enzyme activity and oxidative status in patients with Behçet's diseaseen_US
dc.titleSerum prolidase enzyme activity and oxidative status in patients with Behçet's disease
dc.typeArticleen_US

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