Comprehensive phytochemical analysis of Salvia hispanica L. callus extracts using LC–MS/MS

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dc.authorid0000-0001-7195-2031en_US
dc.authorid0000-0002-3795-0566en_US
dc.authorid0000-0001-7215-9692en_US
dc.authorid0000-0002-4090-7227en_US
dc.contributor.authorÇelik, Şenol
dc.contributor.authorDervişoğlu, Gökhan
dc.contributor.authorİzol, Ebubekir
dc.contributor.authorSęczyk, Łukasz
dc.contributor.authorÖzdemir, Fethi Ahmet
dc.contributor.authorYılmaz, Muhammed Enes
dc.contributor.authorYılmaz, Mustafa Abdullah
dc.date.accessioned2024-08-19T12:14:14Z
dc.date.available2024-08-19T12:14:14Z
dc.date.issued2024en_US
dc.departmentDicle Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümüen_US
dc.description.abstractIn this research, the study utilized the root, leaf, and petiole parts of in vitro grown Salvia hispanica plants as explants. Following UV-C treatment applied to developing callus, methanol extracts were obtained and analyzed using liquid chromatography–mass spectrometry (LC/MS) to investigate their anticancer properties. First, the seeds of S. hispanica were soaked in commercial bleach for 6 min to ensure surface sterilization. The most effective antimicrobial activity on Gram-negative bacteria, with a zone diameter (11 ± 0.82 mm), was noticed in callus extracts obtained from the petiole explant in the second protocol against Klebsiella pneumoniae EMCS bacteria. Anticancer activities on SH-SY5Y human neuroblastoma cells were investigated by using 1000, 500, 250, 125, 62.5, 31.25, 15.62, and 78.12 μg/mL doses of the extracts, and the most effective cytotoxic activity was determined at the 1000 μg/mL dose of the extracts obtained from both protocols. The extracts were determined to inhibit hCAI, hCAII, AChE, and BChE enzymes. The content of 53 different phytochemical components of the extracts was analyzed by liquid chromatography with tandem mass spectrometry (LC–MS/MS). Rosmarinic acid, quinic acid, and caffeic acid were found in the highest concentration. The comprehensive LC–MS/MS analysis of S. hispanica extracts revealed a diverse array of phytochemical compounds, highlighting its potential for therapeutic applications.en_US
dc.identifier.citationÇelik, Ş., Dervişoğlu, G., İzol, E., Sęczyk, Ł., Özdemir, F., A., Yılmaz, M. E. ve diğerleri. (2024). Comprehensive phytochemical analysis of Salvia hispanica L. callus extracts using LC–MS/MS. Biomedical Chromatography, 1-18.en_US
dc.identifier.endpage18en_US
dc.identifier.issn0269-3879
dc.identifier.pmid39105236
dc.identifier.scopus2-s2.0-85200320152
dc.identifier.scopusqualityQ3
dc.identifier.startpage1en_US
dc.identifier.urihttps://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/bmc.5975
dc.identifier.urihttps://hdl.handle.net/11468/28765
dc.identifier.wosWoSIDEksik
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.indekslendigikaynakScopus
dc.institutionauthorYılmaz, Mustafa Abdullah
dc.language.isoenen_US
dc.publisherJohn Wiley and Sons Ltden_US
dc.relation.ispartofBiomedical Chromatography
dc.relation.isversionof10.1002/bmc.5975en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnticancer activityen_US
dc.subjectAntimicrobesen_US
dc.subjectCallusen_US
dc.subjectLC–MS/MSen_US
dc.subjectUV-Cen_US
dc.titleComprehensive phytochemical analysis of Salvia hispanica L. callus extracts using LC–MS/MSen_US
dc.titleComprehensive phytochemical analysis of Salvia hispanica L. callus extracts using LC–MS/MS
dc.typeArticleen_US

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