In vitro and in silico perspectives on biological and phytochemical profile of three halophyte species-A source of innovative phytopharmaceuticals from nature

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dc.contributor.authorZengin, Gokhan
dc.contributor.authorAumeeruddy-Elalfi, Zaahira
dc.contributor.authorMollica, Adriano
dc.contributor.authorYilmaz, Mustafa Abdullah
dc.contributor.authorMahomoodally, Mohamad Fawzi
dc.date.accessioned2024-04-24T16:15:49Z
dc.date.available2024-04-24T16:15:49Z
dc.date.issued2018
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: Halophytes are considered as valuable sources of traditional drugs in different countries. Purpose: The present study aimed to evaluate biological and chemical fingerprints of three halophytes (Arthrocnemum macrostachyum (Moric.) C, Koch, Halimione portulacoides (L.) Aellen and Salicornia europaea L.). Materials and methods: The antioxidant and enzymatic inhibitory potential (acetylcholinesterase, butyrylcholinesterase, alpha-amylase, alpha-glucosidase, and tyrosinase) were assessed. The total phenolic, flavonoid contents, and the chemical profiles were appraised using the ultra-high performance liquid chromatography-electrospray ionization-tandem mass spectrometry. Molecular docking was conducted to provide additional insights of molecular interactions of the enzymes/phytochemicals. Results: Ethyl acetate extract was the most efficient extract, with A. macrostachyum being the most potent towards DPPH and ABTS radicals and phosphomolybdenum assay. Ethyl acetate extract of A. macrostachyum was also the best reducing agent (CUPRAC and FRAP assays). Methanol and ethyl acetate extract of A. macrostachyum, H. portulacoides, and S. europaea showed significant enzyme inhibition potential. Ethyl acetate extract of A. macrostachyum showed the highest total phenolic (29.54 +/- 0.78 mgGAEs/g extract) while the ethyl acetate extract of S. europaea was more abundant in flavonoids (18.26 +/- 0.11 mgREs/g extract). Phytochemical profiling allowed the identification of several components in the methanolic extracts (16 in A. macrostachyum, 14 in H. portulacoides, and 11 in S. europaea), with quinic acid, p-coumaric acid, and rhamnetin being most abundant. Docking studies revealed that the above compounds showed scores for the enzymes tested. Conclusion: The three halophytes studies could be considered as potential sources of biologically-active compounds for novel phytopharmaceuticals development.en_US
dc.identifier.doi10.1016/j.phymed.2017.10.017
dc.identifier.endpage44en_US
dc.identifier.issn0944-7113
dc.identifier.issn1618-095X
dc.identifier.pmid29425653
dc.identifier.scopus2-s2.0-85032898909
dc.identifier.scopusqualityQ1
dc.identifier.startpage35en_US
dc.identifier.urihttps://doi.org/10.1016/j.phymed.2017.10.017
dc.identifier.urihttps://hdl.handle.net/11468/15934
dc.identifier.volume38en_US
dc.identifier.wosWOS:000425172900004
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherElsevier Gmbhen_US
dc.relation.ispartofPhytomedicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHalophyteen_US
dc.subjectNatural Productsen_US
dc.subjectEnzymatic Inhibitionen_US
dc.subjectMolecular Dockingsen_US
dc.subjectUhplc-Esi-Ms/Msen_US
dc.titleIn vitro and in silico perspectives on biological and phytochemical profile of three halophyte species-A source of innovative phytopharmaceuticals from natureen_US
dc.titleIn vitro and in silico perspectives on biological and phytochemical profile of three halophyte species-A source of innovative phytopharmaceuticals from nature
dc.typeArticleen_US

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