Effects of supplemental L-arginine on the intestinal adaptive response after massive small-bowel resection in rats

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dc.contributor.authorÖzturk, H
dc.contributor.authorDokucu, AI
dc.contributor.authorYagmur, Y
dc.contributor.authorSari, I
dc.date.accessioned2024-04-24T16:00:10Z
dc.date.available2024-04-24T16:00:10Z
dc.date.issued2002
dc.departmentDicle Üniversitesien_US
dc.description.abstractTo evaluate whether L-arginine methyl ester (L-Arg) can improve the structure of the small intestine and enhance adaptation in an experimental model of short-bowel syndrome (SBS), 40 Sprague-Dawley rats were divided randomly into four groups of 10 each. In one group only a laparotomy was performed (G1). The remaining 30 rats underwent 90% small-bowel resection (SBR) and formed the three experimental groups: the SBR/untreated group (G2), the SBR/L-NAME-treated group (W), and the SBR/ L-Arg-treated group (G4). Rats in G2 received no therapeutic treatment. Rats in the SBR/L-NAME and SBR/L-Arg treated groups received N-G-nitro-L-arginine-methyl ester (L-NAME) and L-Arg intraperitoneally for 3 weeks, respectively. The animals were weighed daily. All rats underwent a relaparotomy on day 21 of the experiment. Remnant small bowel was excised and evaluated for villus height and crypt cell mitoses. After the 90% SBR, all animals had from diarrhea and weight loss between the 1st and 6th postoperative days (POD). The body weight of the SBR/L-Arg group showed significant increases at POD 10 and 21 in comparison to the SBR/untreated and SBR/L-NAME groups (P < 0.001). The rats treated with L-Arg had significantly greater villus height and crypt-cell mitoses compared to the other groups (P < 0.0001, P < 0.001). These observations suggest that L-Arg treatment increases villus height and crypt-cell mitoses after massive SBR and may play a considerable role in the mucosal adaptive response in SBS in rats.en_US
dc.identifier.doi10.1007/s00383-002-0836-x
dc.identifier.endpage336en_US
dc.identifier.issn0179-0358
dc.identifier.issn1437-9813
dc.identifier.issue5-6en_US
dc.identifier.pmid12415349
dc.identifier.scopus2-s2.0-0036726272
dc.identifier.scopusqualityQ2
dc.identifier.startpage332en_US
dc.identifier.urihttps://doi.org/10.1007/s00383-002-0836-x
dc.identifier.urihttps://hdl.handle.net/11468/14394
dc.identifier.volume18en_US
dc.identifier.wosWOS:000179508000010
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofPediatric Surgery International
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectShort-Bowel Syndromeen_US
dc.subjectNitric Oxideen_US
dc.subjectN-G-Nitro-L-Arginine-Methyl Ester (L-Name)en_US
dc.subjectZl-Arginine-Methyl Ester (L-Arg)en_US
dc.subjectRatsen_US
dc.titleEffects of supplemental L-arginine on the intestinal adaptive response after massive small-bowel resection in ratsen_US
dc.titleEffects of supplemental L-arginine on the intestinal adaptive response after massive small-bowel resection in rats
dc.typeArticleen_US

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