Late failure of combined recombinant hepatitis B vaccine and lamivudine in treatment of a patient with chronic hepatitis B

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dc.contributor.authorYalcin, K
dc.contributor.authorDegertekin, H
dc.contributor.authorBozdayi, M
dc.date.accessioned2024-04-24T17:08:14Z
dc.date.available2024-04-24T17:08:14Z
dc.date.issued2004
dc.departmentDicle Üniversitesien_US
dc.description.abstractWe report the first case of a woman having chronic hepatitis B treated with a combination therapy of recombinant hepatitis B vaccine and lamivudine for 18 months. The main aims of such a combined therapy were to assess whether the concomitant anti-hepatitis B virus (HBV) vaccination might prevent the emergence of a mutant HBV and lead to sustained hepatitis B e antigen seroconversion with undetectable serum HBV DNA. The data from the present case demonstrated that combination of anti-HBV vaccine and lamivudine did not eliminate viral DNA despite prolonged treatment and did not have any effect on preventing resistant-type HBV. Although the combined therapy failed to reach the therapeutic endpoints, it concerned a single and unique patient. Hepatitis B vaccine and lamivudine for HBV treatment should be further investigated in randomized controlled trials.en_US
dc.identifier.doi10.1097/01.SMJ.0000091068.87861.BA
dc.identifier.endpage409en_US
dc.identifier.issn0038-4348
dc.identifier.issn1541-8243
dc.identifier.issue4en_US
dc.identifier.pmid15108839
dc.identifier.scopus2-s2.0-1842730628
dc.identifier.scopusqualityQ2
dc.identifier.startpage407en_US
dc.identifier.urihttps://doi.org/10.1097/01.SMJ.0000091068.87861.BA
dc.identifier.urihttps://hdl.handle.net/11468/17260
dc.identifier.volume97en_US
dc.identifier.wosWOS:000222172200021
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofSouthern Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHepatitis Ben_US
dc.subjectLamivudineen_US
dc.subjectRecombinant Vaccineen_US
dc.titleLate failure of combined recombinant hepatitis B vaccine and lamivudine in treatment of a patient with chronic hepatitis Ben_US
dc.titleLate failure of combined recombinant hepatitis B vaccine and lamivudine in treatment of a patient with chronic hepatitis B
dc.typeArticleen_US

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