Comparison of clinical outcomes in hepatitis B virus–Positive and –Negative renal transplant recipients

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dc.authorid0000-0002-1313-8856en_US
dc.authorid0000-0002-1182-2048en_US
dc.authorid0000-0002-7849-6531en_US
dc.authorid0000-0001-9843-6301en_US
dc.contributor.authorYılmaz, Vural Taner
dc.contributor.authorÇetinkaya, Ramazan
dc.contributor.authorAkbaş, Halide
dc.contributor.authorÖzdem, Sebahat
dc.contributor.authorÜlger, Burak Veli
dc.contributor.authorErbiş, Halil
dc.date.accessioned2023-10-25T11:36:52Z
dc.date.available2023-10-25T11:36:52Z
dc.date.issued2019en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Genel Cerrahi Ana Bilim Dalıen_US
dc.description.abstractOur aim was to compare the short- and long-term clinical outcomes of hepatitis B surface antigen–positive (HbsAgþ) renal transplant recipients with HbsAg- recipients. A total of 204 patients who underwent renal transplantation in our center between 2001 and 2014 were included in the study. The patients were divided into 2 groups. Group 1 was the HbsAg- group (n ¼ 136), and group 2 was the HbsAgþ group (n ¼ 68). There was no significant difference between the groups in terms of lymphocyte crossmatches, numbers of mismatches, immunosuppressive treatment protocols, and induction treatments. In the HbsAgþ group, 51 patients were hepatitis B virus DNAþ, 64 patients were HbeAg-, and 4 patients were HbeAgþ. A total of 57 patients (83.8%) were treated with lamivudine, 4 patients (5.9%) with entecavir, and 7 patients (10.3%) with tenofovir for hepatitis B infection. Graft and patient survival rates, graft functions, acute hepatitis rates, acute rejection rates, and other clinical outcomes of the groups were compared. Demographic data and immunologic risk profiles of the groups were similar. Acute rejection rates, graft survival rates, and patient survival rates were similar. Acute hepatitis rates, glomerular filtration rates on the last controls, and delayed graft function rates were higher in group 2, whereas chronic allograft dysfunction and new-onset diabetes mellitus after transplantation rates were similar between the groups. Our study revealed that graft and patient survival, and acute rejection rates were similar between HbsAgþ and HbsAg- recipients, whereas acute hepatitis rate was higher in HbsAgþ recipients.en_US
dc.identifier.citationYılmaz, V. T., Çetinkaya, R., Akbaş, H., Özdem, S., Ülger, B. V. ve Erbiş, H. (2019). Comparison of clinical outcomes in hepatitis B virus–Positive and –Negative renal transplant recipients. International Surgery, 104(9), 423-430.en_US
dc.identifier.doi10.9738/INTSURG-D-15-00144.1
dc.identifier.endpage430en_US
dc.identifier.issn0020-8868
dc.identifier.issue9en_US
dc.identifier.scopus2-s2.0-85108323381
dc.identifier.scopusqualityQ4
dc.identifier.startpage423en_US
dc.identifier.urihttps://meridian.allenpress.com/international-surgery/article/104/9-10/423/11612/Comparison-of-Clinical-Outcomes-in-Hepatitis-B
dc.identifier.urihttps://hdl.handle.net/11468/12937
dc.identifier.volume104en_US
dc.identifier.wosWOS:000660039700003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorÜlger, Burak Veli
dc.language.isoenen_US
dc.publisherInternational College of Surgeonsen_US
dc.relation.ispartofInternational Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcute hepatitisen_US
dc.subjectAcute rejectionen_US
dc.subjectHepatitis B virusen_US
dc.subjectRenal transplantationen_US
dc.titleComparison of clinical outcomes in hepatitis B virus–Positive and –Negative renal transplant recipientsen_US
dc.titleComparison of clinical outcomes in hepatitis B virus–Positive and –Negative renal transplant recipients
dc.typeArticleen_US

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