Comparison of clinical outcomes in hepatitis B virus–Positive and –Negative renal transplant recipients
Yükleniyor...
Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
International College of Surgeons
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Our aim was to compare the short- and long-term clinical outcomes of hepatitis B surface antigen–positive (HbsAgþ) renal transplant recipients with HbsAg- recipients. A total of 204 patients who underwent renal transplantation in our center between 2001 and 2014 were included in the study. The patients were divided into 2 groups. Group 1 was the HbsAg- group (n ¼ 136), and group 2 was the HbsAgþ group (n ¼ 68). There was no significant difference between the groups in terms of lymphocyte crossmatches, numbers of mismatches, immunosuppressive treatment protocols, and induction treatments. In the HbsAgþ group, 51 patients were hepatitis B virus DNAþ, 64 patients were HbeAg-, and 4 patients were HbeAgþ. A total of 57 patients (83.8%) were treated with lamivudine, 4 patients (5.9%) with entecavir, and 7 patients (10.3%) with tenofovir for hepatitis B infection. Graft and patient survival rates, graft functions, acute hepatitis rates, acute rejection rates, and other clinical outcomes of the groups were compared. Demographic data and immunologic risk profiles of the groups were similar. Acute rejection rates, graft survival rates, and patient survival rates were similar. Acute hepatitis rates, glomerular filtration rates on the last controls, and delayed graft function rates were higher in group 2, whereas chronic allograft dysfunction and new-onset diabetes mellitus after transplantation rates were similar between the groups. Our study revealed that graft and patient survival, and acute rejection rates were similar between HbsAgþ and HbsAg- recipients, whereas acute hepatitis rate was higher in HbsAgþ recipients.
Açıklama
Anahtar Kelimeler
Acute hepatitis, Acute rejection, Hepatitis B virus, Renal transplantation
Kaynak
International Surgery
WoS Q Değeri
Q4
Scopus Q Değeri
Q4
Cilt
104
Sayı
9
Künye
Yılmaz, V. T., Çetinkaya, R., Akbaş, H., Özdem, S., Ülger, B. V. ve Erbiş, H. (2019). Comparison of clinical outcomes in hepatitis B virus–Positive and –Negative renal transplant recipients. International Surgery, 104(9), 423-430.
