p21WAF-1/CIP-1, a downstream regulator of functional p53 loss, in transitional cell carcinoma of urothelium

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dc.contributor.authorÖzdemir, E
dc.contributor.authorKakehi, Y
dc.contributor.authorYoshida, O
dc.date.accessioned2024-04-24T17:12:19Z
dc.date.available2024-04-24T17:12:19Z
dc.date.issued2000
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjectives: The expression of p21(WAF-1/CIP-1), a downstream regulator of p53, is a universal cycline-dependent kinase inhibitor. The aim of this study is to determine whether p21 expression could be used as a prognostic marker in urothelial carcinomas. Methods: By use of immunohistochemistry, we examined the expression of p21(WAF-1/CIP-1) in 60 patients with urothelial carcinomas and compared the results with the status of nuclear p53 and mdm2 accumulation, expression of type IV collagen in the basement membranes and upregulation of metalloproteinases (MMP-1, MMP-2, MMP-9). Results: p21(WAF-1/CIP-1) immunoreactivity was observed in 51.7% of the tumors, and in only 39% of the tumors with functional p53 loss (nuclear accumulation of p53 and/or mdm2). p21(WAF-1/CIP-1) overexpression was not associated with grade and stage of the tumors and presence or absence of concomitant CIS, Moreover, p21(WAF-1/CIP-1) overexpression was not associated with upregulation of metalloproteinases or destruction of type IV collagen of basement membranes. Conclusions: Our results suggest that p21(WAF-1/CIP-1) expression is regulated by both p53-dependent and independent pathways and is not related to grade, stage or potential markers of invasion in urothelial carcinomas. Copyright (C) 2000 S. Karger AG. Basel.en_US
dc.identifier.doi10.1159/000020284
dc.identifier.endpage234en_US
dc.identifier.issn0302-2838
dc.identifier.issue2en_US
dc.identifier.pmid10895017
dc.identifier.scopus2-s2.0-0033938961
dc.identifier.scopusqualityQ1
dc.identifier.startpage230en_US
dc.identifier.urihttps://doi.org/10.1159/000020284
dc.identifier.urihttps://hdl.handle.net/11468/17929
dc.identifier.volume38en_US
dc.identifier.wosWOS:000088295300019
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofEuropean Urology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectP21(Waf1/Cip-1)en_US
dc.subjectP53en_US
dc.subjectMdm2en_US
dc.subjectType Iv Collagenen_US
dc.subjectMetalloproteinasesen_US
dc.subjectTransitional Cell Carcinomaen_US
dc.titlep21WAF-1/CIP-1, a downstream regulator of functional p53 loss, in transitional cell carcinoma of urotheliumen_US
dc.titlep21WAF-1/CIP-1, a downstream regulator of functional p53 loss, in transitional cell carcinoma of urothelium
dc.typeArticleen_US

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