Effects of isotretinoin on obsessive compulsive symptoms, depression, and anxiety in patients with acne vulgaris

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dc.contributor.authorYesilova, Yavuz
dc.contributor.authorBez, Yasin
dc.contributor.authorAri, Mustafa
dc.contributor.authorKaya, Mehmet Cemal
dc.contributor.authorAlpak, Gokay
dc.date.accessioned2024-04-24T17:20:30Z
dc.date.available2024-04-24T17:20:30Z
dc.date.issued2012
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: Depression, anxiety, and obsessive compulsive symptoms are known to be common among patients with acne vulgaris. In contrast to earlier reports, a number of recent studies suggested isotretinoin to be beneficial for depression and anxiety symptoms in acne patients. Moreover, its effects on obsessive compulsive symptomatology are still widely unknown. Objectives: To examine the effects of isotretinoin treatment on obsessive compulsive symptoms, depression, and anxiety in acne vulgaris patients. Methods: The Hospital Anxiety and Depression Scale, Maudsley Obsessive Compulsive Questionnaire, and Sheehan Disability Scale were administered to 43 patients with acne vulgaris who accepted isotretinoin treatment and agreed to participate in the study. Severity of acne was evaluated with Global Acne Grading System. Thirty-three patients completed 6 months treatment with oral isotretinoin at 0.5-1.0 mg/kg daily doses. Measurements were repeated at the end of 6 months. Results: Depression, anxiety, and obsessive rumination symptoms were significantly improved after isotretinoin treatment. On the other hand, obsessive doubting of acne patients was worse at the end of the treatment. There was no significant change in disease related disability of patients. Conclusion: Besides worsening of obsessive doubting, successful treatment with oral isotretinoin seems to be related with improvement in depression, anxiety, and obsessive rumination symptoms in acne vulgaris patients. These changes were not reflected in the disability level that acne patients have reported.en_US
dc.identifier.doi10.3109/09546634.2011.608782
dc.identifier.endpage271en_US
dc.identifier.issn0954-6634
dc.identifier.issn1471-1753
dc.identifier.issue4en_US
dc.identifier.pmid21815780
dc.identifier.scopus2-s2.0-84863903081
dc.identifier.scopusqualityQ1
dc.identifier.startpage268en_US
dc.identifier.urihttps://doi.org/10.3109/09546634.2011.608782
dc.identifier.urihttps://hdl.handle.net/11468/19091
dc.identifier.volume23en_US
dc.identifier.wosWOS:000306437200005
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofJournal of Dermatological Treatment
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcneen_US
dc.subjectIsotretinoinen_US
dc.subjectDepressionen_US
dc.subjectAnxietyen_US
dc.subjectObsessionen_US
dc.subjectCompulsionen_US
dc.subjectDisabilityen_US
dc.titleEffects of isotretinoin on obsessive compulsive symptoms, depression, and anxiety in patients with acne vulgarisen_US
dc.titleEffects of isotretinoin on obsessive compulsive symptoms, depression, and anxiety in patients with acne vulgaris
dc.typeArticleen_US

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