Early prognostic markers to predict unsuccessful pregnancy in dairy cattle

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dc.authoridYOKUS, BERAN/0000-0003-4585-3712
dc.authoridTAKCI, Abdurrahman/0000-0002-0569-7957
dc.contributor.authorYokus, Beran
dc.contributor.authorTakci, Abdurrahman
dc.contributor.authorErcan, Nazli
dc.contributor.authorEm, Bernan
dc.contributor.authorUysal, Ersin
dc.date.accessioned2025-02-22T14:08:52Z
dc.date.available2025-02-22T14:08:52Z
dc.date.issued2024
dc.departmentDicle Üniversitesien_US
dc.description.abstractThis study aimed to investigate maternal serum levels of some angiogenic factors and certain proteins in dairy cattle for (1) early prediction of unsuccessful fertilization and (2) early detection of possible pregnancy failures (early EM) after positive insemination Serum samples were collected from the same cattle at three distinct time points: 30 days before artificial insemination (B-AI), on the day of artificial insemination (AI), and 30 days after artificial insemination (A-AI). As a result of the pregnancy examination, the cows were divided into two main groups according to whether they were pregnant. The results showed that leucyl/cystinyl aminopeptidase (LNPEP) concentration was significantly decreased B-AI and Secreted frizzled-related proteins (SFRP-3), Vascular Endothelial Growth Factor (VEGF) and LNPEP levels were significantly decreased on day of AI, while PRL level was increased, and these data have prognostic significance as early indicator of the risk of potentially failed pregnancy. Additionally, a significant decrease in LNPEP, SFRP3, and VEGF levels, along with an increase in PRL levels was also observed in A-AI. These results suggest that these biomarkers can be used as a screening test to monitor the course of pregnancy. There were no significant differences in serum levels of Insulin-Like Growth Factor 2 (IGF-2), Tissue inhibitors of metalloproteinases (TIMP-1), angiopoietin (ANG), Endoglin (ENG), Fibroblast growth factor (FGF), Inhibine-A (INH-A) and Transforming growth factors-beta 1 (TGF-beta 1) between the evaluated periods neither unsuccessful nor the successful pregnancy groups. This is the first study reporting that the maternal serum levels of LNPEP, SFRP3, VEGF, and PRL have important roles in pregnancy success and may indicate whether insemination outcome will be successful B-AI and predict the risk of unsuccessful pregnancy after AI in dairy cattle. The increase in such studies will allow the development of more specific, practical, and applicable markers.en_US
dc.identifier.doi10.1111/rda.14587
dc.identifier.issn0936-6768
dc.identifier.issn1439-0531
dc.identifier.issue5en_US
dc.identifier.pmid38812420en_US
dc.identifier.scopus2-s2.0-85194883906en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1111/rda.14587
dc.identifier.urihttps://hdl.handle.net/11468/29686
dc.identifier.volume59en_US
dc.identifier.wosWOS:001235020500001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofReproduction in Domestic Animalsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKA_WOS_20250222
dc.subjectangiogenic factoren_US
dc.subjectdairy cattleen_US
dc.subjectembryonic mortalityen_US
dc.subjectfertilization successen_US
dc.subjectLNPEP (PLAP)en_US
dc.subjectpregnancy lossen_US
dc.subjectSFRP3en_US
dc.titleEarly prognostic markers to predict unsuccessful pregnancy in dairy cattleen_US
dc.typeArticleen_US

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