Effects of Ellagic Acid on Copper, Zinc, and Biochemical Values in Serum and Liver of Experimental Cholestatic Rats

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dc.contributor.authorGumus, Metehan
dc.contributor.authorYuksel, Hatice
dc.contributor.authorEvliyaoglu, Osman
dc.contributor.authorKapan, Murat
dc.contributor.authorBoyuk, Abdullah
dc.contributor.authorOnder, Akin
dc.contributor.authorAldemir, Mustafa
dc.date.accessioned2024-04-24T16:02:38Z
dc.date.available2024-04-24T16:02:38Z
dc.date.issued2011
dc.departmentDicle Üniversitesien_US
dc.description.abstractEllagic acid (EA) is a natural polyphenolic compound. Although, modulator effects of EA on copper (Cu) and zinc (Zn) levels in some liver diseases have been reported in experimental animals, its effects in obstructive jaundice (OJ) has not been clarified. We aimed to evaluate potential effects of EA on Cu and Zn levels in liver and serum of cholestatic rats. Forty Wistar albino rats were equally divided into four groups. First group was used as controls. Second group received EA (60 mg(-1) kg(-1) day(-1)) for 8 days. Third was OJ group, and fourth group was OJ plus EA group. After 8 days, blood and liver samples were obtained. Higher serum and liver Cu and lower serum and liver Zn levels were found in OJ group (p < 0.05) compared with other groups. However, these differences reached to significant levels for Cu in serum and for Zn in lever. Higher serum copper levels were decreased, and lower liver Zn levels were increased by EA treatment in cholestatic rats (p < 0.05). Also, higher Cu/Zn ratio in OJ group was decreased by EA treatment both in liver (p < 0.05) and in serum (p < 0.05). Significantly higher serum bilirubin, alkaline phosphatase, alanine aminotransferase, and aspartate aminotransferase values were found in OJ and OJ + EA groups compared with the control and EA groups (p < 0.05). In conclusion, result of the current study indicated that ellagic acid has modulator effects on Cu and Zn levels in liver and serum of cholestatic rats.en_US
dc.identifier.doi10.1007/s12011-010-8863-2
dc.identifier.endpage393en_US
dc.identifier.issn0163-4984
dc.identifier.issn1559-0720
dc.identifier.issue1en_US
dc.identifier.pmid20882364
dc.identifier.scopus2-s2.0-80054775335
dc.identifier.scopusqualityQ1
dc.identifier.startpage386en_US
dc.identifier.urihttps://doi.org/10.1007/s12011-010-8863-2
dc.identifier.urihttps://hdl.handle.net/11468/14862
dc.identifier.volume143en_US
dc.identifier.wosWOS:000295033600038
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherHumana Press Incen_US
dc.relation.ispartofBiological Trace Element Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCholestasisen_US
dc.subjectTrace Elementsen_US
dc.subjectEllagic Aciden_US
dc.subjectLiveren_US
dc.subjectObstructive Jaundiceen_US
dc.titleEffects of Ellagic Acid on Copper, Zinc, and Biochemical Values in Serum and Liver of Experimental Cholestatic Ratsen_US
dc.titleEffects of Ellagic Acid on Copper, Zinc, and Biochemical Values in Serum and Liver of Experimental Cholestatic Rats
dc.typeArticleen_US

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