Pharmacokinetics and bioavailability of danofloxacin in chukar partridge (Alectoris chukar) following intravenous, intramuscular, subcutaneous, and oral administrations

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dc.contributor.authorCorum, Orhan
dc.contributor.authorCorum, Duygu Durna
dc.contributor.authorAtik, Orkun
dc.contributor.authorFaki, Hatice Eser
dc.contributor.authorAltan, Feray
dc.contributor.authorUney, Kamil
dc.date.accessioned2024-04-24T17:11:46Z
dc.date.available2024-04-24T17:11:46Z
dc.date.issued2019
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe aim of the present study was to determine the pharmacokinetics (PKs) and bioavailability of danofloxacin in chukar partridge (Alectoris chukar) following intravenous (IV), intramuscular (IM), subcutaneous (SC), and oral (PO) administrations at a dose of 10 mg/kg. A total of eight clinically healthy chukar partridges weighing 480 +/- 45 g were used for the investigation. The study was performed in a crossover design (2 x 2 x 2 x 2) with a 15-day washout period between two administrations in four periods. The plasma concentrations of danofloxacin were determined using reversed-phase high-performance liquid chromatography. Noncompartmental PK parameters were also estimated. No local or systemic adverse drug effects were observed in any of the chukar partridges. The mean elimination half-life ranged between 8.18 and 12.08 hr and differed statistically among administration routes. The mean peak plasma concentrations of danofloxacin following IM, SC, and PO administrations were 8.05, 9.58, and 3.39 mu g/ml at 0.5, 1, and 4 hr, respectively. Following IM, SC, and PO administrations, the mean bioavailability was 86.33%, 134.40%, and 47.62%, respectively. The mean total clearance and volume of distribution at steady-state following IV administration were 0.13 L hr(-1) kg(-1) and 0.96 L/kg, respectively. These data, including favorable PKs and the absence of adverse drug effects, suggest that danofloxacin is a useful antibiotic in chukar partridges.en_US
dc.identifier.doi10.1111/jvp.12737
dc.identifier.endpage213en_US
dc.identifier.issn0140-7783
dc.identifier.issn1365-2885
dc.identifier.issue2en_US
dc.identifier.pmid30474236
dc.identifier.scopus2-s2.0-85057225795
dc.identifier.scopusqualityQ1
dc.identifier.startpage207en_US
dc.identifier.urihttps://doi.org/10.1111/jvp.12737
dc.identifier.urihttps://hdl.handle.net/11468/17716
dc.identifier.volume42en_US
dc.identifier.wosWOS:000460077600009
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Veterinary Pharmacology and Therapeutics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBioavailabilityen_US
dc.subjectChukar Partridgeen_US
dc.subjectDanofloxacinen_US
dc.subjectPharmacokineticsen_US
dc.titlePharmacokinetics and bioavailability of danofloxacin in chukar partridge (Alectoris chukar) following intravenous, intramuscular, subcutaneous, and oral administrationsen_US
dc.titlePharmacokinetics and bioavailability of danofloxacin in chukar partridge (Alectoris chukar) following intravenous, intramuscular, subcutaneous, and oral administrations
dc.typeArticleen_US

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