Arterial distensibility in patients with ruptured and unruptured intracranial aneurysms: Is it a predisposing factor for rupture risk?

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dc.contributor.authorDusak, Abdurrahim
dc.contributor.authorKamasak, Kaan
dc.contributor.authorGoya, Cemil
dc.contributor.authorAdin, Mehmet E.
dc.contributor.authorElbey, Mehmet A.
dc.contributor.authorBilici, Aslan
dc.date.accessioned2024-04-24T17:15:06Z
dc.date.available2024-04-24T17:15:06Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: A risk factor assessment that reliably predicts whether patients are predisposed to intracranial aneurysm (IA) rupture has yet to be formulated. As such, the clinical management of unruptured IA remains unclear. Our aim was to determine whether impaired arterial distensibility and hypertrophic remodeling might be indicators of risk for IA rupture. Material/Methods: The study population (n=49) was selected from consecutive admissions for either unruptured IA (n=23) or ruptured IA (n=26) from January to December 2010. Hemodynamic measures were taken from every patient, including systolic and diastolic blood pressure using a sphygmomanometer. Unruptured IA and ruptured IA characteristics, including aneurysmal shape, size, angle, aspect ratio, and bottleneck factor, were measured and calculated from transverse brain CT angiography images. With ultrasound, the right common carotid artery intima-media thickness was measured, as well as the lumen diameter during systole and diastole. Arterial wall strain, distensibility, stiffness index, and elastic modulus were calculated and compared between patients with unruptured IAs and ruptured IAs. A p-value less than 0.05 was considered statistically significant. Results: General demographic data did not differ between patients with unruptured IAs and ruptured IAs. Greater mean intima-media thickness (p=0.013), mean stiffness index (p=0.044), and mean elastic modulus (p=0.026) were observed for patients with ruptured IAs. Moreover, mean strain (p=0.013) and mean distensibility (p=0.024) were decreased in patients with ruptured IAs. Conclusions: Patients with ruptured IAs demonstrated decreased arterial distensibility and increased intima-media thickness at the level of the carotid arteries. By measuring these parameters via ultrasound, it may be possible to predict whether patients with existing IAs might rupture and hemorrhage into the subarachnoid space.en_US
dc.identifier.doi10.12659/MSM.889032
dc.identifier.endpage709en_US
dc.identifier.issn1643-3750
dc.identifier.pmid23974299
dc.identifier.scopus2-s2.0-84883178486
dc.identifier.scopusqualityQ1
dc.identifier.startpage703en_US
dc.identifier.urihttps://doi.org/10.12659/MSM.889032
dc.identifier.urihttps://hdl.handle.net/11468/18338
dc.identifier.volume19en_US
dc.identifier.wosWOS:000323481300001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherInt Scientific Information, Incen_US
dc.relation.ispartofMedical Science Monitor
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectRuptureden_US
dc.subjectIntracranial Aneurysmen_US
dc.subjectPredisposing Factorsen_US
dc.subjectElasticityen_US
dc.subjectCarotid Intima-Media Thicknessen_US
dc.subjectUltrasounden_US
dc.titleArterial distensibility in patients with ruptured and unruptured intracranial aneurysms: Is it a predisposing factor for rupture risk?en_US
dc.titleArterial distensibility in patients with ruptured and unruptured intracranial aneurysms: Is it a predisposing factor for rupture risk?
dc.typeArticleen_US

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