Coenzyme Q10, Copper, Zinc, and Lipid Peroxidation Levels in Serum of Patients with Chronic Obstructive Pulmonary Disease

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dc.contributor.authorTanrikulu, Abdullah Cetin
dc.contributor.authorAbakay, Abdurrahman
dc.contributor.authorEvliyaoglu, Osman
dc.contributor.authorPalanci, Yilmaz
dc.date.accessioned2024-04-24T16:02:38Z
dc.date.available2024-04-24T16:02:38Z
dc.date.issued2011
dc.departmentDicle Üniversitesien_US
dc.description.abstractSeverity of chronic obstructive pulmonary disease (COPD) exacerbation is associated with increased level of copper (Cu), zinc (Zn), and lipid peroxidation (malodialdehyde, MDA). The aim of this study was to investigate the levels of lipid peroxidation, Coenzyme Q10 (CoQ10), Zn, and Cu in the COPD exacerbations. Forty-five patients with COPD acute exacerbation and 45 healthy smokers as control group were used in the study. Forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) were lower in exacerbation group than in control. C- reactive protein levels, white blood cell count, and sedimentation rate were significantly (p < 0.001) higher in patients than in control. CoQ10 level and Cu/Zn ratio was significantly (p < 0.05) lower in patients than in control, although MDA, Cu, and Zn levels were significantly (p < 0.05) higher in patients than in control. Negative correlations were found among MDA, Cu, Zn, FEV1, and FVC values in exacerbation and control subjects (p < 0.05). In conclusion, we observed that oxidative stress in the exacerbation period of COPD patients was increased. The decrease in CoQ10 level and Cu/Zn ratio and elevation in Cu and Zn levels observed in the patients probably result from the defense response of organism and are mediated by inflammatory-like substances.en_US
dc.identifier.doi10.1007/s12011-010-8897-5
dc.identifier.endpage667en_US
dc.identifier.issn0163-4984
dc.identifier.issue2en_US
dc.identifier.pmid21080098
dc.identifier.scopus2-s2.0-80054752313
dc.identifier.scopusqualityQ1
dc.identifier.startpage659en_US
dc.identifier.urihttps://doi.org/10.1007/s12011-010-8897-5
dc.identifier.urihttps://hdl.handle.net/11468/14863
dc.identifier.volume143en_US
dc.identifier.wosWOS:000295609300006
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherHumana Press Incen_US
dc.relation.ispartofBiological Trace Element Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChronic Obstructive Pulmonary Diseaseen_US
dc.subjectExacerbationen_US
dc.subjectOxidative Stressen_US
dc.subjectCoenzyme Q10en_US
dc.subjectCopperen_US
dc.subjectZincen_US
dc.titleCoenzyme Q10, Copper, Zinc, and Lipid Peroxidation Levels in Serum of Patients with Chronic Obstructive Pulmonary Diseaseen_US
dc.titleCoenzyme Q10, Copper, Zinc, and Lipid Peroxidation Levels in Serum of Patients with Chronic Obstructive Pulmonary Disease
dc.typeArticleen_US

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