Elevated levels of cortisol, brain-derived neurotropic factor and tissue plasminogen activator in male children with autism spectrum disorder

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dc.contributor.authorBozkurt, Hasan
dc.contributor.authorŞimşek, Şeref
dc.contributor.authorŞahin, Serkan
dc.contributor.orcid0000-0002-5099-6833
dc.date.accessioned2024-04-24T15:59:20Z
dc.date.available2024-04-24T15:59:20Z
dc.date.issued2021
dc.departmentDicle Üniversitesi, Tıp Faküştesi, Dahili Tıp Bilimleri Bölümü, Çocuk ve Ergen Ruh Sağlığı Hastalıkları Ana Bilim Dalıen_US
dc.description.abstractSeveral studies demonstrated biological effects of cortisol, brain-derived neurotrophic factor (BDNF) and tissue plasminogen activator (tPA) on human metabolism and central nervous system. Our study investigated the serum levels of tPA along with BDNF and cortisol in children with autism spectrum disorder (ASD). Thirty three male children with ASD ranging in age from 2 to 15 years were selected for the study group and 27 age-matched healthy male children were selected for the control group. The ASD severity was determined by the score on the Autism Behavior Checklist (ABC). The mean cortisol levels for the study group and the control group were 79.1 +/- 30.2 ng/ml and 60.0 +/- 25.1 ng/ml, respectively. The mean BDNF levels for the study group and the control group were 5.9 +/- 2.8 ng/ml and 3.7 +/- 1.8 ng/ml, respectively. The mean tPA levels for the study group and the control group were 32.9 +/- 18.5 ng/ml and 25.5 +/- 15.1 ng/ml, respectively. Cortisol, BDNF and tPA levels were significantly higher in the study group compared to the control group (p < 0.001). There was no statistically significant effect in terms of age, ABC total and subscale scores on serum cortisol, BDNF and tPA levels in the study group (p > 0.05). It may be suggested that elevations may indicate a role in the pathogenesis of ASD or it may be the case that ASD may alter the levels or pathways of these metabolic factors. Lay Summary The underlying mechanism or a specific metabolic target relevant to autism spectrum disorder (ASD) has not yet been identified. Cortisol, brain-derived neurotrophic factor (BDNF) and tissue plasminogen activator (tPA) have biological effects on neuroplasticity but little is known about the role of cortisol and tPA-BDNF pathway in ASD. In the present study focused on male children with ASD, we have found higher blood levels of cortisol, BDNF and tPA than their healthy peers. This is the first clinical study to evaluate the serum tPA levels along with BDNF and cortisol in ASD. The results suggest that several neurotrophic and other related markers should be born in mind while examining children with ASD.en_US
dc.identifier.citationBozkurt, H., Şimşek, Ş. ve Şahin, S. (2021). Elevated levels of cortisol, brain-derived neurotropic factor and tissue plasminogen activator in male children with autism spectrum disorder. Autism Research, 14(10), 2078-2084.
dc.identifier.doi10.1002/aur.2582
dc.identifier.endpage2084en_US
dc.identifier.issn1939-3792
dc.identifier.issn1939-3806
dc.identifier.issue10en_US
dc.identifier.pmid34291889
dc.identifier.scopus2-s2.0-85110961277
dc.identifier.scopusqualityQ1
dc.identifier.startpage2078en_US
dc.identifier.urihttps://doi.org/10.1002/aur.2582
dc.identifier.urihttps://hdl.handle.net/11468/13985
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/epdf/10.1002/aur.2582
dc.identifier.volume14en_US
dc.identifier.wosWOS:000675413200001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorŞimşek, Şeref
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofAutism Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAutismen_US
dc.subjectBrain-derived neurotrophic factoren_US
dc.subjectCortisolen_US
dc.subjectTissue plasminogen activatoren_US
dc.titleElevated levels of cortisol, brain-derived neurotropic factor and tissue plasminogen activator in male children with autism spectrum disorderen_US
dc.titleElevated levels of cortisol, brain-derived neurotropic factor and tissue plasminogen activator in male children with autism spectrum disorder
dc.typeArticleen_US

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