Comparison of 18F-FDG PET/CT and 68Ga-FAPI-04 PET/CT in patients with non-small cell lung cancer

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dc.contributor.authorCan, Canan
dc.contributor.authorKepenek, Ferat
dc.contributor.authorKomek, Halil
dc.contributor.authorGundogan, Cihan
dc.contributor.authorKaplan, Ihsan
dc.contributor.authorTasdemir, Bekir
dc.contributor.authorGuzel, Yunus
dc.date.accessioned2024-04-24T17:08:22Z
dc.date.available2024-04-24T17:08:22Z
dc.date.issued2022
dc.departmentDicle Üniversitesien_US
dc.description.abstractAim In this study, we aimed to compare the diagnostic accuracy of F-18-fluorodeoxyglucose (F-18-FDG) and Gallium-68 labeled fibroblast activator protein inhibitor (Ga-68-FAPI)-04 PET/CT in the tumor-node-metastasis (TNM) staging of patients with nonsmall cell lung cancer (NSCLC) and investigate whether adenocarcinoma (ADC) and squamous cell cancer (SCC) exhibit different uptake patterns on Ga-68-FAPI-04 PET/CT. Materials and method Twenty-nine patients with a histopathologically-confirmed diagnosis of NSCLC, who had no history of previous radiation therapy or chemotherapy and underwent F-18-FDG PET/CT and Ga-68-FAPI-04 PET/CT imaging between January 2021 and December 2021 were included in this retrospective study. Staging was performed using the 8th edition of the TNM staging system on both F-18-FDG PET/CT and Ga-68-FAPI-04 PET/CT images. Standardized uptake value (SUV)(max) and tumor-to-background ratios (TBR) were calculated on primary lesions and metastases. Results There was no statistically significant difference in primary lesions in terms of SUVmax and TBR values. However, Ga-68-FAPI-04 PET/CT was significantly superior to F-18-FDG PET/CT in terms of the number of lymph nodes and bone metastases revealed. The SUVmax and TBR values of lymph nodes, hepatic lesions and bone lesions were significantly higher on Ga-68-FAPI-04 PET/CT than on F-18-FDG PET/CT. Ga-68-FAPI-04 PET/CT changed the disease stage of three patients (10.9%). The diagnostic accuracy of Ga-68-FAPI-04 PET/CT was 100%, whereas the diagnostic accuracy of F-18-FDG PET/CT was 89.6% (P = 0.250). Conclusion Although Ga-68-FAPI-04 PET/CT detected more lesions and higher diagnostic accuracy than F-18-FDG PET/CT in NSCLC, neither method was statistically superior to each other in terms of diagnostic accuracy in TNM staging.en_US
dc.identifier.doi10.1097/MNM.0000000000001607
dc.identifier.endpage1091en_US
dc.identifier.issn0143-3636
dc.identifier.issn1473-5628
dc.identifier.issue10en_US
dc.identifier.pmid35972340
dc.identifier.scopus2-s2.0-85138448291
dc.identifier.scopusqualityQ3
dc.identifier.startpage1084en_US
dc.identifier.urihttps://doi.org/10.1097/MNM.0000000000001607
dc.identifier.urihttps://hdl.handle.net/11468/17319
dc.identifier.volume43en_US
dc.identifier.wosWOS:000853493400005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofNuclear Medicine Communications
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectF-18- Fdgen_US
dc.subjectGa-68-Fapi-04en_US
dc.subjectNsclcen_US
dc.subjectPeten_US
dc.subjectCten_US
dc.subjectSuvmaxen_US
dc.titleComparison of 18F-FDG PET/CT and 68Ga-FAPI-04 PET/CT in patients with non-small cell lung canceren_US
dc.titleComparison of 18F-FDG PET/CT and 68Ga-FAPI-04 PET/CT in patients with non-small cell lung cancer
dc.typeArticleen_US

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