High levels of high sensitivity C-reactive protein predict the progression of chronic rheumatic mitral stenosis

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dc.contributor.authorAlyan, Omer
dc.contributor.authorMetin, Fatma
dc.contributor.authorKacmaz, Fehmi
dc.contributor.authorOzdemir, Ozcan
dc.contributor.authorMaden, Orhan
dc.contributor.authorTopaloglu, Serkan
dc.contributor.authorDemir, Ahmet Duran
dc.date.accessioned2024-04-24T16:02:21Z
dc.date.available2024-04-24T16:02:21Z
dc.date.issued2009
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground High sensitive C-Reactive Protein (hs-CRP) predicts morbidity and mortality in various clinical conditions. The effect of hsCRP on progression of chronic rheumatic mitral stenosis (CRMS) has not been demonstrated. Methods and results A total of 132 patients with CRMS (95 female, 37 male) and 145 control (100 female, 45 male) were included in the study. Baseline clinical, echocardiographic, hematologic and hs-CRP measurements were collected prospectively. Mean mitral valve area (MVA) was 1.4 +/- 0.3 cm(2), mean wilkins valve score value was 8.9 +/- 1.7, left atrial diameter was 5.0 +/- 0.7 cm, left atrial area was 37.2 +/- 12.6 cm(2), and systolic pulmonary arterial pressure (SPAP) was 44 +/- 11 mmHg in patients with CRMS. The mean levels of hs-CRP value, fibrinogen, and mean platelet volume (MPV) were significantly higher in CRMS group compared to control group. The levels of hsCRP were found to be positively correlated with mean Wilkins valve score value, SPAP, presence of atrial fibrillation (AF), left atrial diameter, left atrial area, presence of LASEC(+), fibrinogen, and MPV and inversely correlated with MVA in patients with CRMS. Linear regression analysis revealed that the hsCRP level independently affects mean Wilkins valve score value, left atrial area (LAA), LASEC(+) and AF in the patients with CRMS. Conclusions These results suggest that increased hsCRP levels are associated with CRMS severity. These association may be important when treating patients with CRMS.en_US
dc.identifier.doi10.1007/s11239-008-0245-7
dc.identifier.endpage69en_US
dc.identifier.issn0929-5305
dc.identifier.issue1en_US
dc.identifier.pmid18622582
dc.identifier.scopus2-s2.0-67449095441
dc.identifier.scopusqualityQ1
dc.identifier.startpage63en_US
dc.identifier.urihttps://doi.org/10.1007/s11239-008-0245-7
dc.identifier.urihttps://hdl.handle.net/11468/14757
dc.identifier.volume28en_US
dc.identifier.wosWOS:000266911900011
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Thrombosis and Thrombolysis
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHigh Sensitive C-Reactive Proteinen_US
dc.subjectMitral Stenosisen_US
dc.subjectWilkins Scoreen_US
dc.titleHigh levels of high sensitivity C-reactive protein predict the progression of chronic rheumatic mitral stenosisen_US
dc.titleHigh levels of high sensitivity C-reactive protein predict the progression of chronic rheumatic mitral stenosis
dc.typeArticleen_US

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