Comprehensive metabolite profiling of berdav propolis using LC-MS/MS: Determination of antioxidant, anticholinergic, antiglaucoma, and antidiabetic effects

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dc.authorid0000-0001-6912-3998en_US
dc.authorid0000-0002-4090-7227en_US
dc.authorid0000-0002-1750-1966en_US
dc.authorid0000-0002-0833-3358en_US
dc.authorid0000-0001-5993-1668en_US
dc.contributor.authorKarageçili, Hasan
dc.contributor.authorYılmaz, Mustafa Abdullah
dc.contributor.authorErtürk, Adem
dc.contributor.authorKızıltaş, Hatice
dc.contributor.authorGüven, Leyla
dc.contributor.authorAlwasel, Saleh H.
dc.contributor.authorGülçin, İlhami
dc.date.accessioned2023-09-28T13:03:54Z
dc.date.available2023-09-28T13:03:54Z
dc.date.issued2023en_US
dc.departmentDicle Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümüen_US
dc.description.abstractPropolis is a complex natural compound that honeybees obtain from plants and contributes to hive safety. It is rich in phenolic and flavonoid compounds, which contain antioxidant, antimicrobial, and anticancer properties. In this study, the chemical composition and antioxidant activities of propolis were investigated; ABTS•+, DPPH• and DMPD•+ were prepared using radical scavenging antioxidant methods. The phenolic and flavonoid contents of propolis were 53 mg of gallic acid equivalent (GAE)/g and 170.164 mg of quercetin equivalent (QE)/g, respectively. The ferric ion (Fe3+) reduction, CUPRAC and FRAP reduction capacities were also studied. The antioxidant and reducing capacities of propolis were compared with those of butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), α-tocopherol and Trolox reference standards. The half maximal inhibition concentration (IC50) values of propolis for ABTS•+, DPPH• and DMPD•+ scavenging activities were found to be 8.15, 20.55 and 86.64 μg/mL, respectively. Propolis extract demonstrated IC50 values of 3.7, 3.4 and 19.6 μg/mL against α-glycosidase, acetylcholinesterase (AChE) and carbonic anhydrase II (hCA II) enzyme, respectively. These enzymes’ inhibition was associated with diabetes, Alzheimer’s disease (AD) and glaucoma. The reducing power, antioxidant activity and enzyme inhibition capacity of propolis extract were comparable to those demonstrated by the standards. Twenty-eight phenolic compounds, including acacetin, caffeic acid, p-coumaric acid, naringenin, chrysin, quinic acid, quercetin, and ferulic acid, were determined by LC-MS/MS to be major organic compounds in propolis. The polyphenolic antioxidant-rich content of the ethanol extract of propolis appears to be a natural product that can be used in the treatment of diabetes, AD, glaucoma, epilepsy, and cancerous diseases.en_US
dc.identifier.citationKarageçili, H., Yılmaz, M. A., Ertürk, A., Kızıltaş, H., Güven, L., Alwasel, S. H. ve diğerleri. (2023). Comprehensive metabolite profiling of berdav propolis using LC-MS/MS: Determination of antioxidant, anticholinergic, antiglaucoma, and antidiabetic effects. Molecules, 28(4), 1-20.en_US
dc.identifier.doi10.3390/molecules28041739
dc.identifier.endpage20en_US
dc.identifier.issn1420-3049
dc.identifier.issue4en_US
dc.identifier.pmid36838726
dc.identifier.scopus2-s2.0-85149052865
dc.identifier.scopusqualityQ1
dc.identifier.startpage1en_US
dc.identifier.urihttps://www.mdpi.com/1420-3049/28/4/1739
dc.identifier.urihttps://hdl.handle.net/11468/12625
dc.identifier.volume28en_US
dc.identifier.wosWOS:000941732200001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorYılmaz, Mustafa Abdullah
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.relation.ispartofMolecules
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPropolisen_US
dc.subjectAntioxidant activityen_US
dc.subjectα-glycosidaseen_US
dc.subjectAcetylcholinesteraseen_US
dc.subjectCarbonic anhydraseen_US
dc.subjectPhenolic compounden_US
dc.titleComprehensive metabolite profiling of berdav propolis using LC-MS/MS: Determination of antioxidant, anticholinergic, antiglaucoma, and antidiabetic effectsen_US
dc.titleComprehensive metabolite profiling of berdav propolis using LC-MS/MS: Determination of antioxidant, anticholinergic, antiglaucoma, and antidiabetic effects
dc.typeArticleen_US

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