Prolidase activity and oxidative status in patients with thalassemia major

Basit Öğe Kaydı
dc.contributor.authorÇakmak, Alpay
dc.contributor.authorSöker, Murat
dc.contributor.authorKoç, Ahmet
dc.contributor.authorAksoy, Nurten
dc.contributor.orcid0000-0001-8463-2723
dc.date.accessioned2024-04-24T15:59:25Z
dc.date.available2024-04-24T15:59:25Z
dc.date.issued2010
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalıen_US
dc.description.abstractAim: Prolidase is a specific imidodipepticlase involved in collagen degradation. The increase in the enzyme activity is believed to be correlated with the increased intensity of collagen degradation. The study aimed to evaluate the relationship between prolidase activity and oxidative status in patients with thalassemia major. Methods: Comparison was made between 87 patients diagnosed with thalassemia major and 33 healthy children of similar age and gender. Mean age of the subjects was 7.5 +/- 4.3 years in the group of patients with thalassemia major and 8.9 +/- 3.1 years in the control group. Serum prolidase activity was measured spectrophotometrically. Oxidative status was determined using total oxidant status (TOS), total antioxidant capacity (TAC), and oxidative stress index (OSI) measurement. Results: Prolidase activity was significantly increased in patients with thalassemia major (53.7 +/- 8.7U/l) compared to the control group (49.2 +/- 7.2 U/l, P<0.001). TOS was significantly increased in the patient group (5.31 +/- 3.14 mmol H2O2 equiv./l) compared to the control group (3.49 +/- 2.98 mmol H2O2 equiv./l) and the OSI was also significantly increased in the patient group (3.86 +/- 3.28 arbitrary unit) compared to the control group (2.53 +/- 2.70 arbitrary unit) (P<0.0001 and P<0.001, respectively), while there were no significant differences between the patient (1.61 +/- 0.30 mu mol Trolox equiv./l) and control (1.64 +/- 0.33 mu mol Trolox equiv./l) groups with respect to TAC. Conclusion: Significant increases in prolidase activity in patients with thalassemia major may constitute a key parameter in demonstrating a disorder of the collagen metabolism.en_US
dc.identifier.citationÇakmak, A., Söker, M., Koç, A. ve Aksoy, N. (2010). Prolidase activity and oxidative status in patients with thalassemia major. Journal of Clinical Laboratory Analysis, 24(1), 6-11.
dc.identifier.doi10.1002/jcla.20361
dc.identifier.endpage11en_US
dc.identifier.issn0887-8013
dc.identifier.issn1098-2825
dc.identifier.issue1en_US
dc.identifier.pmid20087956
dc.identifier.scopus2-s2.0-75749126542
dc.identifier.scopusqualityQ1
dc.identifier.startpage6en_US
dc.identifier.urihttps://doi.org/10.1002/jcla.20361
dc.identifier.urihttps://hdl.handle.net/11468/14057
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/10.1002/jcla.20361
dc.identifier.volume24en_US
dc.identifier.wosWOS:000274403200002
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorSöker, Murat
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Clinical Laboratory Analysis
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectThalassemia majoren_US
dc.subjectProlidase activityen_US
dc.subjectCollagenen_US
dc.subjectOxidative statusen_US
dc.titleProlidase activity and oxidative status in patients with thalassemia majoren_US
dc.titleProlidase activity and oxidative status in patients with thalassemia major
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Prolidase Activity and Oxidative Status in Patients with Thalassemia Major.pdf
Boyut:
98.54 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Makale Dosyası
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu