Dynamic multidetector computed tomography findings of hepatocellular carcinoma of hepatitis B virus-positive and -negative patients
dc.contributor.author | Senturk, Senem | |
dc.contributor.author | Cetin, Bulent | |
dc.contributor.author | Cengiz, Mustafa | |
dc.contributor.author | Bilici, Aslan | |
dc.contributor.author | Ozekinci, Selver | |
dc.date.accessioned | 2024-04-24T17:14:51Z | |
dc.date.available | 2024-04-24T17:14:51Z | |
dc.date.issued | 2014 | |
dc.department | Dicle Üniversitesi | en_US |
dc.description.abstract | Background: The objective of this study was to retrospectively investigate and compare multidetector computed tomography findings of hepatocellular carcinoma (HCC) in hepatitis B virus (HBV)-positive and -negative patients. Methods: Triphasic (arterial, portal venous, and delayed phases) dynamic multidetector computed tomography (CT) was performed in 83 patients with HCC, 48 of whom were HBV-positive. The diagnosis of HCC was established with typical CT imaging findings (68 patients) or histopathological evaluation (15 patients). Distribution of solitary, multiple, and diffuse HCC, portal/hepatic vein thrombosis, metastasis, and patients with high alpha-fetoprotein levels in the HBV-positive and -negative groups were compared using the Kolmogorov-Smirnov test. Lesion size, alpha-fetoprotein levels, arterial, portal, delayed enhancement, and washout of lesions were compared using the Student's t-test. Results: Hypervascular tumors were observed in 72 (87%) patients, and hypovascular tumors were found in 11 (13%) patients. The mean alpha-fetoprotein value of HBV-positive patients with HCC was significantly higher than the mean alpha-fetoprotein value of HBV-negative patients (P < 0.05). Portal/hepatic vein thrombosis and metastasis were more frequently observed in HBV-positive patients (P < 0.05). The frequencies of solitary, multiple, and diffuse lesions in HBV-positive and -negative patients were not significantly different (P > 0.05). The mean diameters, arterial, portal, and delayed phase attenuations, and washout of HCC were not significantly different (P > 0.05). Conclusions: Multidetector CT imaging findings of HCC in HBV-positive and -negative patients are alike. Portal/hepatic vein thrombosis and metastasis are more frequently observed in HBV-positive patients. Alpha-fetoprotein levels are higher in HBV-positive patients. | en_US |
dc.identifier.doi | 10.1186/1470-7330-14-9 | |
dc.identifier.issn | 1470-7330 | |
dc.identifier.issn | 1740-5025 | |
dc.identifier.pmid | 25608603 | |
dc.identifier.scopus | 2-s2.0-84941218972 | |
dc.identifier.scopusquality | Q1 | |
dc.identifier.uri | https://doi.org/10.1186/1470-7330-14-9 | |
dc.identifier.uri | https://hdl.handle.net/11468/18226 | |
dc.identifier.volume | 14 | en_US |
dc.identifier.wos | WOS:000343694300009 | |
dc.identifier.wosquality | Q2 | |
dc.indekslendigikaynak | Web of Science | |
dc.indekslendigikaynak | Scopus | |
dc.indekslendigikaynak | PubMed | |
dc.language.iso | en | en_US |
dc.publisher | E-Med | en_US |
dc.relation.ispartof | Cancer Imaging | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Multidetector Computed Tomography | en_US |
dc.subject | Hepatocellular Carcinoma | en_US |
dc.subject | Hepatitis B Virus | en_US |
dc.subject | Dynamic Imaging | en_US |
dc.title | Dynamic multidetector computed tomography findings of hepatocellular carcinoma of hepatitis B virus-positive and -negative patients | en_US |
dc.title | Dynamic multidetector computed tomography findings of hepatocellular carcinoma of hepatitis B virus-positive and -negative patients | |
dc.type | Article | en_US |