Dynamic multidetector computed tomography findings of hepatocellular carcinoma of hepatitis B virus-positive and -negative patients

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dc.contributor.authorSenturk, Senem
dc.contributor.authorCetin, Bulent
dc.contributor.authorCengiz, Mustafa
dc.contributor.authorBilici, Aslan
dc.contributor.authorOzekinci, Selver
dc.date.accessioned2024-04-24T17:14:51Z
dc.date.available2024-04-24T17:14:51Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: The objective of this study was to retrospectively investigate and compare multidetector computed tomography findings of hepatocellular carcinoma (HCC) in hepatitis B virus (HBV)-positive and -negative patients. Methods: Triphasic (arterial, portal venous, and delayed phases) dynamic multidetector computed tomography (CT) was performed in 83 patients with HCC, 48 of whom were HBV-positive. The diagnosis of HCC was established with typical CT imaging findings (68 patients) or histopathological evaluation (15 patients). Distribution of solitary, multiple, and diffuse HCC, portal/hepatic vein thrombosis, metastasis, and patients with high alpha-fetoprotein levels in the HBV-positive and -negative groups were compared using the Kolmogorov-Smirnov test. Lesion size, alpha-fetoprotein levels, arterial, portal, delayed enhancement, and washout of lesions were compared using the Student's t-test. Results: Hypervascular tumors were observed in 72 (87%) patients, and hypovascular tumors were found in 11 (13%) patients. The mean alpha-fetoprotein value of HBV-positive patients with HCC was significantly higher than the mean alpha-fetoprotein value of HBV-negative patients (P < 0.05). Portal/hepatic vein thrombosis and metastasis were more frequently observed in HBV-positive patients (P < 0.05). The frequencies of solitary, multiple, and diffuse lesions in HBV-positive and -negative patients were not significantly different (P > 0.05). The mean diameters, arterial, portal, and delayed phase attenuations, and washout of HCC were not significantly different (P > 0.05). Conclusions: Multidetector CT imaging findings of HCC in HBV-positive and -negative patients are alike. Portal/hepatic vein thrombosis and metastasis are more frequently observed in HBV-positive patients. Alpha-fetoprotein levels are higher in HBV-positive patients.en_US
dc.identifier.doi10.1186/1470-7330-14-9
dc.identifier.issn1470-7330
dc.identifier.issn1740-5025
dc.identifier.pmid25608603
dc.identifier.scopus2-s2.0-84941218972
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1186/1470-7330-14-9
dc.identifier.urihttps://hdl.handle.net/11468/18226
dc.identifier.volume14en_US
dc.identifier.wosWOS:000343694300009
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherE-Meden_US
dc.relation.ispartofCancer Imaging
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMultidetector Computed Tomographyen_US
dc.subjectHepatocellular Carcinomaen_US
dc.subjectHepatitis B Virusen_US
dc.subjectDynamic Imagingen_US
dc.titleDynamic multidetector computed tomography findings of hepatocellular carcinoma of hepatitis B virus-positive and -negative patientsen_US
dc.titleDynamic multidetector computed tomography findings of hepatocellular carcinoma of hepatitis B virus-positive and -negative patients
dc.typeArticleen_US

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