Phenolic content and biomolecule oxidation protective activity of Globularia alypum extracts

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dc.authorid0000-0002-3472-0538en_US
dc.authorid0000-0001-8946-647Xen_US
dc.authorid0000-0003-0133-5630en_US
dc.authorid0000-0002-9578-3786en_US
dc.authorid0000-0001-9603-0631en_US
dc.contributor.authorBouriche, Hamama
dc.contributor.authorKada, Seoussen
dc.contributor.authorSenator, Abderrahmane
dc.contributor.authorDemirtaş, İbrahim
dc.contributor.authorÖzen, Tevfik
dc.contributor.authorToptancı, Bircan Çeken
dc.contributor.authorKızıl, Göksel
dc.contributor.authorKızıl, Murat
dc.date.accessioned2023-11-28T06:03:46Z
dc.date.available2023-11-28T06:03:46Z
dc.date.issued2017en_US
dc.departmentDicle Üniversitesi, Fen Fakültesi, Kimya Bölümüen_US
dc.description.abstractThe protective activity of methanolic (Met E) and aqueous (Aq E) extracts of Globularia alypum L. (G. alypum) against DNA, lipid and protein oxidative damage was investigated. Moreover, the scavenging, chelating, and reducing power activities of the extracts were also evaluated. Phytochemical analysis was performed to determine phenolic compounds. Results showed that Met E and Aq E were rich in phenolic compounds, and were able to scavenge DPPH* with IC50 values of 48.61 μg/mL and 51.97 μg/mL, respectively. In addition, both extracts were able to chelate ferrous ions. At 300 μg/mL, the chelating activity was 97.53% and 91.02%, respectively. The reducing power of these extracts was also remarkable and concentration dependent. At 100 μg/mL, both extracts inhibited lipid peroxidatin by only 42.45% and 4.03%. However, the DNA oxidation damage was inhibited dose-dependently in the presence of G. alypum extracts. At 1 mg/mL, both extracts suppressed DNA cleavage by 83%-84%. The protein oxidation was also inhibited by G. alypum extracts. At 1 mg/mL, Aq E and Met E protected BSA fragmentation by 77%-99%. The overall results suggest that G. alypum extracts exerted antioxidant activity and protect biomolecules against oxidative damage; hence it may serve as a potential source of natural antioxidants.en_US
dc.identifier.citationBouriche, H., Kada, S., Senator, A., Demirtaş, İ., Özen, T., Toptancı, B. Ç. ve diğerleri. (2017). Phenolic content and biomolecule oxidation protective activity of Globularia alypum extracts. Brazilian Archives of Biology and Technology, 60, 1-15.en_US
dc.identifier.doi10.1590/1678-4324-2017160409
dc.identifier.endpage15en_US
dc.identifier.issn1516-8913
dc.identifier.scopus2-s2.0-85041494386
dc.identifier.scopusqualityQ2
dc.identifier.startpage1en_US
dc.identifier.urihttps://www.scielo.br/j/babt/a/MNdyGLxByG9KzwkgcXbsfcq/?lang=en
dc.identifier.urihttps://hdl.handle.net/11468/13053
dc.identifier.volume60en_US
dc.identifier.wosWOS:000410077000001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorToptancı, Bircan Çeken
dc.institutionauthorKızıl, Göksel
dc.institutionauthorKızıl, Murat
dc.language.isoenen_US
dc.publisherInstituto de Tecnologia do Paranaen_US
dc.relation.ispartofBrazilian Archives of Biology and Technology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntioxidantsen_US
dc.subjectDNA damageen_US
dc.subjectGlobularia alypumen_US
dc.subjectLipid peroxidationen_US
dc.subjectProtein oxidationen_US
dc.titlePhenolic content and biomolecule oxidation protective activity of Globularia alypum extractsen_US
dc.titlePhenolic content and biomolecule oxidation protective activity of Globularia alypum extracts
dc.typeArticleen_US

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