Sulphonamides incorporating 1,3,5-triazine structural motifs show antioxidant, acetylcholinesterase, butyrylcholinesterase, and tyrosinase inhibitory profile

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dc.authorid0000-0003-4163-9962en_US
dc.contributor.authorLolak, Nabih
dc.contributor.authorBoǧa, Mehmet
dc.contributor.authorTuneğ, Muhammed
dc.contributor.authorKarakoç, Gulçin
dc.contributor.authorAkocak, Suleyman
dc.contributor.authorSupuran, Claudiu T.
dc.date.accessioned2021-09-06T06:30:41Z
dc.date.available2021-09-06T06:30:41Z
dc.date.issued2020en_US
dc.departmentDicle Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümüen_US
dc.descriptionPMID:31899985
dc.description.abstractA series of 16 novel benzenesulfonamides incorporating 1,3,5-triazine moieties substituted with aromatic amines, dimethylamine, morpholine and piperidine were investigated. These compounds were assayed for antioxidant properties by using 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging assay, 2,2`-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS) radical decolarisation assay and metal chelating methods. They were also investigated as inhibitors of acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and tyrosinase, which are associated with several diseases such as Alzheimer, Parkinson and pigmentation disorders. These benzenesulfonamides showed moderate DPPH radical scavenging and metal chelating activity, and low ABTS cation radical scavenging activity. Compounds 2 b, 3d and 3 h showed inhibitory potency against AChE with % inhibition values of >90. BChE was also effectively inhibited by most of the synthesised compounds with >90% inhibition potency. Tyrosinase was less inhibited by these compounds.en_US
dc.identifier.citationLolak, N., Boǧa, M., Tuneğ, M., Karakoç, G., Akocak, S. ve Supuran, C. T. (2020). Sulphonamides incorporating 1,3,5-triazine structural motifs show antioxidant, acetylcholinesterase, butyrylcholinesterase, and tyrosinase inhibitory profile. Journal of Enzyme Inhibition and Medicinal Chemistry, 35(1), 424-431.en_US
dc.identifier.doi10.1080/14756366.2019.1707196
dc.identifier.endpage431en_US
dc.identifier.issn1475-6366
dc.identifier.issue1en_US
dc.identifier.pmid31899985
dc.identifier.scopus2-s2.0-85077303675
dc.identifier.scopusqualityQ1
dc.identifier.startpage424en_US
dc.identifier.urihttps://www.tandfonline.com/doi/full/10.1080/14756366.2019.1707196
dc.identifier.urihttps://hdl.handle.net/11468/7439
dc.identifier.volume35en_US
dc.identifier.wosWOS:000505406200001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBoǧa, Mehmet
dc.institutionauthorTuneğ, Muhammed
dc.language.isoenen_US
dc.publisherTaylor and Francis Ltden_US
dc.relation.ispartofJournal of Enzyme Inhibition and Medicinal Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject1,3,5-triazineen_US
dc.subjectAlzheimer’s diseaseen_US
dc.subjectBenzenesulfonamidesen_US
dc.subjectEnzyme inhibitionen_US
dc.subjectTyrosinaseen_US
dc.titleSulphonamides incorporating 1,3,5-triazine structural motifs show antioxidant, acetylcholinesterase, butyrylcholinesterase, and tyrosinase inhibitory profileen_US
dc.titleSulphonamides incorporating 1,3,5-triazine structural motifs show antioxidant, acetylcholinesterase, butyrylcholinesterase, and tyrosinase inhibitory profile
dc.typeArticleen_US

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