Evaluation of clinical and cytogenetic findings on 1,068 second-trimester amniocenteses in Southeast Turkey

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dc.contributor.authorBalkan, M.
dc.contributor.authorAkbas, H.
dc.contributor.authorKalkanli, S.
dc.contributor.authorSakar, M. N.
dc.contributor.authorFidanboy, M.
dc.contributor.authorAlp, M. N.
dc.contributor.authorBudak, T.
dc.date.accessioned2024-04-24T17:33:51Z
dc.date.available2024-04-24T17:33:51Z
dc.date.issued2011
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: To investigate the indications of amniocentesis for the detection of chromosomal abnormalities among a sample of patients in Southeast Turkey. Material and Methods: Between 2004 and 2007, 1,068 second-trimester amniocentesis tests were performed in the Medical Biology and Genetics Department Laboratory at Dicle University. Amniotic fluids were cultured by using long-term tissue culture for prenatal diagnosis with cytogenetic analysis. The clinical and cytogenetic findings on 1,068 second-trimester amniocenteses were analyzed. The indications, the proportions of karyotypes according to indications and complications were summarized. Results: Among the 1,068 amniocentesis cases, the maternal age between 35 and 39 years was the most common age group (34.5%). Of the clinical indications abnormal maternal serum screening results were the most common indication for amniocentesis (37.6%). Of 52 cases (4.9%) with detected chromosomal aberrations, 39 were numeric (27 trisomies, 10 sex chromosome aberrations and two triploidies) and 13 were structural (2 reciprocal translocations, 2 Robertsonian translocations and 6 inversions). The highest detection rate of chromosome aberrations was in cases undergoing amniocentesis for abnormal maternal serum screening combined with abnormal ultrasound (US) findings (8.0%). Conclusion: This study suggests that complementary measures, such as routine antenatal US and maternal serum screening, should be added to increase the efficiency of genetic amniocentesis. Therefore, the study could be used for the establishment of a database for genetic counseling.en_US
dc.identifier.endpage368en_US
dc.identifier.issn0390-6663
dc.identifier.issue4en_US
dc.identifier.pmid22268276
dc.identifier.scopus2-s2.0-84856978877
dc.identifier.scopusqualityQ4
dc.identifier.startpage364en_US
dc.identifier.urihttps://hdl.handle.net/11468/20863
dc.identifier.volume38en_US
dc.identifier.wosWOS:000297948600017
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisher7847050 Canada Incen_US
dc.relation.ispartofClinical and Experimental Obstetrics & Gynecology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAmniocentesisen_US
dc.subjectChromosome Aberrationsen_US
dc.subjectGenetic Counselingen_US
dc.subjectPrenatal Diagnosisen_US
dc.titleEvaluation of clinical and cytogenetic findings on 1,068 second-trimester amniocenteses in Southeast Turkeyen_US
dc.titleEvaluation of clinical and cytogenetic findings on 1,068 second-trimester amniocenteses in Southeast Turkey
dc.typeArticleen_US

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