Comparison of tuberculin skin test and a specific T-cell-based test, T-Spot™.TB, for the diagnosis of latent tuberculosis infection

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dc.contributor.authorOzekinci, T.
dc.contributor.authorOzbek, E.
dc.contributor.authorCelik, Y.
dc.date.accessioned2024-04-24T17:14:42Z
dc.date.available2024-04-24T17:14:42Z
dc.date.issued2007
dc.departmentDicle Üniversitesien_US
dc.description.abstractThere is substantial evidence that the detection of T cells specific for the proteins ESAT-6 and CFP-10 using the ex vivo enzyme-linked immunospot technique is a marked improvement on the existing tuberculin skin test (TST). This new technique, which detects,gamma-interferon-producing T cells, is now available as the commercial assay, T-Spot (TM).TB. We compared the T-Spot (TM).TB test with the TST for the diagnosis of latent tuberculosis infection (LTBI) in different groups of subjects. Significant accordance (85.7%) between the tests was found in subjects with active lung tuberculosis and in tuberculosis clinic and laboratory personnel (63.6%) but accordance was lowest and not significant amongst house contacts of tuberculosis patients (53.6%). We conclude that, in countries where vaccination is routinely performed, the T-Spot (TM).TB test is a useful diagnostic test for LTBI in highrisk groups when carried out either together with the TST and/or to confirm the TST result.en_US
dc.identifier.doi10.1177/147323000703500515
dc.identifier.endpage703en_US
dc.identifier.issn0300-0605
dc.identifier.issn1473-2300
dc.identifier.issue5en_US
dc.identifier.pmid17944056
dc.identifier.scopus2-s2.0-35348871011
dc.identifier.scopusqualityQ2
dc.identifier.startpage696en_US
dc.identifier.urihttps://doi.org/10.1177/147323000703500515
dc.identifier.urihttps://hdl.handle.net/11468/18150
dc.identifier.volume35en_US
dc.identifier.wosWOS:000249791600015
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofJournal of International Medical Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLatent Tuberculosisen_US
dc.subjectInterferon-Gammaen_US
dc.subjectTuberculin Skin Testen_US
dc.subjectT-Spot (Tm).Tben_US
dc.titleComparison of tuberculin skin test and a specific T-cell-based test, T-Spot™.TB, for the diagnosis of latent tuberculosis infectionen_US
dc.titleComparison of tuberculin skin test and a specific T-cell-based test, T-Spot™.TB, for the diagnosis of latent tuberculosis infection
dc.typeArticleen_US

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