Investigation of anticardiolipin antibodies in chronic hepatitis B infection together with total anti-delta positivity

dc.contributor.authorMese, Sevim
dc.contributor.authorOezekinci, Tuncer
dc.contributor.authorAtmaca, Selahattin
dc.contributor.authorArikan, Eralp
dc.contributor.authorAkin, Davut
dc.date.accessioned2024-04-24T17:37:34Z
dc.date.available2024-04-24T17:37:34Z
dc.date.issued2008
dc.departmentDicle Üniversitesien_US
dc.description.abstractAnticardiolipin antibodies (ACAs) are formed against phospholipids in various clinical conditions such as autoimmune diseases, malignancy, infectious diseases, alcohol-related and hepatic cirrhosis. The aims of this study were to investigate the presence of ACAs in patients with chronic hepatitis B together with positive total anti-delta antibodies, and to investigate the relationship between age, gender, and some laboratory parameters (ALT, AST, albumin, globulin, platelet number) of patients with chronic hepatitis delta virus (HDV) infection, who were positive or negative for ACAs. A total of 60 patients (43 male, 17 female) with chronic hepatitis D infection [HBsAg positive, HBeAg negative, anti-HBe positive, anti-HBc IgG positive, anti-HBc IgM negative, total anti-delta positive, anti-HCV negative] and 30 patients (21 male, 9 female) without hepatitis D infection [HBsAg positive, HBeAg negative, anti-HBe positive, anti-HBc IgG positive, anti-HBc IgM negative, total anti-delta negative, anti-HCV negative] as control group were included to the study. ACA IgG and IgM were searched by a commercial microELISA kit (Euroimmun, Germany). The statistical evaluation was performed with Pearson's chi-square test, Student's t-test, and Fisher's exact test. Total ACAs positivity rate of 60 patients with chronic HDV infection, was found as 13.3%, in which four of the patients were positive for only ACA IgM, while four was positive for only IgG. Positivity for both ACA IgG and ACA IgM could not be detected in these patients. No patients in the control group had positivity for ACAs (IgG and/or IgM). A statistically significant difference was observed in terms of ACA positivity between patients with and without HDV infection (p<0.05). After all, there was no statistically significant correlation between ACAs positivity and the age, sex, and laboratory parameters of the patients with chronic HIDV infection, except lower serum albumin levels (p=0.004). Although the data of this study revealed a statistically significant positive correlation between chronic HDV infection and anticardiolipin antibodies, it is clear that there is a need for further studies on this subject.en_US
dc.identifier.endpage487en_US
dc.identifier.issn0374-9096
dc.identifier.issue3en_US
dc.identifier.pmid18822893
dc.identifier.scopus2-s2.0-52349106541
dc.identifier.scopusqualityQ3
dc.identifier.startpage483en_US
dc.identifier.urihttps://hdl.handle.net/11468/21028
dc.identifier.volume42en_US
dc.identifier.wosWOS:000258416900014
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isotren_US
dc.publisherAnkara Microbiology Socen_US
dc.relation.ispartofMikrobiyoloji Bulteni
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHepatitis Ben_US
dc.subjectHepatitis Deltaen_US
dc.subjectAnticardiolipin Antibodiesen_US
dc.titleInvestigation of anticardiolipin antibodies in chronic hepatitis B infection together with total anti-delta positivityen_US
dc.titleInvestigation of anticardiolipin antibodies in chronic hepatitis B infection together with total anti-delta positivity
dc.typeArticleen_US

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