Relationship between lesions in adenomatous polyp-dysplasia-colorectal cancer sequence and neutrophil-to-lymphocyte ratio

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dc.authorid0000-0002-2677-3971en_US
dc.authorid0000-0002-0908-1949en_US
dc.contributor.authorUçmak, Feyzullah
dc.contributor.authorTuncel, Elif Tuğba
dc.date.accessioned2024-04-03T13:03:08Z
dc.date.available2024-04-03T13:03:08Z
dc.date.issued2016en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıklar Ana Bilim Dalıen_US
dc.description.abstractBackground: The aim of our study was to evaluate all lesions in the adenoma-dysplasia-cancer sequence of the colon and to examine whether the neutrophil-to-lymphocyte ratio (NLR) can distinguish polyps indicating dysplasia and cancer. Material/Methods: A total of 397 patients who had colonoscopic polypectomy between January 2010 and December 2014 were included in our retrospective study. The patients were divided into four groups: patients with hyperplastic polyps, patients with adenomatous polyps, patients with dysplasia, and patients with cancer. The NLR was calculated as a simple ratio indicating the relationship between counts of absolute neutrophil and absolute lymphocyte. Results: The NLR increased in line with the adenomatous polyp-dysplasia-cancer sequence, with the highest ratio established among cancer patients (2.05 (0.27–10), 2.34 (0.83–14.70) and 3.25 (0.81–10.0), respectively). The NLR was significantly higher among cancer patients than among patients with adenomatous polyps and hyperplastic polyps (p values were 0.001 and 0.004, respectively). The lymphocyte count of cancer patients was prominently lower when compared to those in groups with adenomatous polyps and hyperplastic polyps (p values were 0.001 and 0.003, respectively). The NLR was found to be significantly higher in patients with polyps larger than 10 mm [2.71 (0.90–14.70)] when compared to those with polyps smaller than 10 mm [2.28 (0.27–11.67)] (p<0.001). With the NLR threshold set at 2.20, it was possible to predict cancerous polyps with a sensitivity of 71.4% and a specificity of 52.5% (AUC: 0.665, 95% CI: 0.559–0.772, p=0.001). Conclusions: NLR is a cheap, universally available, simple and reliable test that can help predict cancerous polyps. It can be used as a non-invasive test for monitoring polyps.en_US
dc.identifier.citationUçmak, F. ve Tuncel, E. T. (2016). Relationship between lesions in adenomatous polyp-dysplasia-colorectal cancer sequence and neutrophil-to-lymphocyte ratio. Medical Science Monitor, 22, 4536-4541.en_US
dc.identifier.doi10.12659/MSM.898879
dc.identifier.endpage4541en_US
dc.identifier.issn1234-1010
dc.identifier.pmid27881836
dc.identifier.scopus2-s2.0-84997822274
dc.identifier.scopusqualityQ1
dc.identifier.startpage4536en_US
dc.identifier.urihttps://medscimonit.com/abstract/index/idArt/898879
dc.identifier.urihttps://hdl.handle.net/11468/13818
dc.identifier.volume22en_US
dc.identifier.wosWOS:000388361100001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorUçmak, Feyzullah
dc.institutionauthorTuncel, Elif Tuğba
dc.language.isoenen_US
dc.publisherInternational Scientific Literature Inc.en_US
dc.relation.ispartofMedical Science Monitor
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectColonic polypsen_US
dc.subjectColorectal neoplasmsen_US
dc.subjectLymphocyte counten_US
dc.subjectNeutrophilsen_US
dc.titleRelationship between lesions in adenomatous polyp-dysplasia-colorectal cancer sequence and neutrophil-to-lymphocyte ratioen_US
dc.titleRelationship between lesions in adenomatous polyp-dysplasia-colorectal cancer sequence and neutrophil-to-lymphocyte ratio
dc.typeArticleen_US

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