Epidermal growth factor and glucocorticoid effects on blood prostaglandin E(2) level in DENA-induced carcinogenesis

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dc.contributor.authorGonul, B
dc.contributor.authorSoylemezoglu, T
dc.contributor.authorErbas, D
dc.date.accessioned2024-04-24T16:18:55Z
dc.date.available2024-04-24T16:18:55Z
dc.date.issued1996
dc.departmentDicle Üniversitesien_US
dc.description.abstractThis paper describes results on carcinogenesis in rats induced with diethylnitrosamine (DENA; 280 mg/kg single dose, i.p.). After inducing chemical carcinogenesis, the animals were treated with different compounds that affect cell proliferation and the effects on the blood prostaglandin E(2) (PGE(2)) levels were observed. These compounds were epidermal growth factor (EGF, 10 mu g/kg/24 h i.p., 7 days) and dexamethasone (4 mg/kg/24 h i.p., 7 days). The blood PGE(2) levels of rats were measured by RIA (Radioimmunoassay). The blood PGE(2) levels increased significantly following DENA and EGF administrations alone or together. Dexamethasone administration decreased the blood PGE(2) levels. In conclusion the data show that the increase in the plasma PGE(2) level by DENA treatment was enhanced by EGF but opposed by dexamethasone. This suggests that EGF may be effective as a promoter in chemical carcinogenesis.en_US
dc.identifier.doi10.1016/S0952-3278(96)90006-X
dc.identifier.endpage260en_US
dc.identifier.issn0952-3278
dc.identifier.issue4en_US
dc.identifier.pmid8951994
dc.identifier.scopus2-s2.0-0029806187
dc.identifier.scopusqualityQ2
dc.identifier.startpage257en_US
dc.identifier.urihttps://doi.org/10.1016/S0952-3278(96)90006-X
dc.identifier.urihttps://hdl.handle.net/11468/16333
dc.identifier.volume55en_US
dc.identifier.wosWOS:A1996VU43100007
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherChurchill Livingstoneen_US
dc.relation.ispartofProstaglandins Leukotrienes and Essential Fatty Acids
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[No Keyword]en_US
dc.titleEpidermal growth factor and glucocorticoid effects on blood prostaglandin E(2) level in DENA-induced carcinogenesisen_US
dc.titleEpidermal growth factor and glucocorticoid effects on blood prostaglandin E(2) level in DENA-induced carcinogenesis
dc.typeArticleen_US

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