Pituitary Carcinoma Presenting With Multiple Metastases: Case Report

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dc.contributor.authorGuzel, Aslan
dc.contributor.authorTatli, Mehmet
dc.contributor.authorSenturk, Senem
dc.contributor.authorGuzel, Ebru
dc.contributor.authorCayli, Suleyman Rustu
dc.contributor.authorSav, Aydin
dc.date.accessioned2024-04-24T17:14:36Z
dc.date.available2024-04-24T17:14:36Z
dc.date.issued2008
dc.departmentDicle Üniversitesien_US
dc.description.abstractPituitary carcinoma, an uncommon tumor in adults, generally presents with craniospinal and systemic metastases. We report a case of pituitary carcinoma with multiple craniospinal metastases in a child. A 9-year-old girl, who had had a ventriculoperitoneal shunt operation 3 years ago, presented with complaints of progressive visual disturbance, headache, speech difficulty, and gait disturbance for the past 2 months. Neurological examination revealed papilledema, visual loss, and dysarthria. Cranial magnetic resonance imaging revealed a large contrast-enhanced tumor in the left frontal region together with multiple lesions in the sellar-parasellar region and posterior fossa. Multiple intraspinal contrast-enhanced metastatic lesions were also seen. Histopathological and immunohistochemical examination of the excised left frontal mass revealed pituitary carcinoma. Treatment with cyclic temozolomide was started after the operation, but the patient died after 2 months Without response to medical therapy. This is the first pediatric case, to the authors' knowledge, Of a pituitary carcinoma with widespread intracranial and intraspinal metastases.en_US
dc.identifier.doi10.1177/0883073808319078
dc.identifier.endpage1471en_US
dc.identifier.issn0883-0738
dc.identifier.issue12en_US
dc.identifier.pmid19073854
dc.identifier.scopus2-s2.0-57749204302
dc.identifier.scopusqualityQ1
dc.identifier.startpage1467en_US
dc.identifier.urihttps://doi.org/10.1177/0883073808319078
dc.identifier.urihttps://hdl.handle.net/11468/18090
dc.identifier.volume23en_US
dc.identifier.wosWOS:000261121700017
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofJournal of Child Neurology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPituitary Carcinomaen_US
dc.subjectIntracranial Metastasisen_US
dc.subjectSpinal Metastasisen_US
dc.titlePituitary Carcinoma Presenting With Multiple Metastases: Case Reporten_US
dc.titlePituitary Carcinoma Presenting With Multiple Metastases: Case Report
dc.typeArticleen_US

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