Assessment of epicardial adipose tissue thickness and the mean platelet volume in children with familial Mediterranean fever

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dc.contributor.authorUluca, Unal
dc.contributor.authorDemir, Fikri
dc.contributor.authorEce, Aydin
dc.contributor.authorSen, Velat
dc.contributor.authorGunes, Ali
dc.contributor.authorAktar, Fesih
dc.contributor.authorTan, Ilhan
dc.date.accessioned2024-04-24T17:14:55Z
dc.date.available2024-04-24T17:14:55Z
dc.date.issued2015
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: Familial Mediterranean fever (FMF) is an inflammatory disease, which is suggested to be associated with increased risk of atherosclerosis. Epicardial adipose tissue (EAT) thickness and the mean platelet volume (MPV) are parameters used in prediction of atherosclerotic risk in various conditions. These parameters were evaluated in children with FMF and compared with healthy controls. Methods: Forty-five patients with FMF and 54 age-and gender-matched healthy controls were assessed. Duration of symptoms, age at diagnosis, duration of delay in diagnosis, frequency and duration of FMF attacks, disease severity scores, response to colchicine therapy, MEditerraneanFeVer (MEFV) gene mutations, and MPV values were recorded. EAT thicknesses were measured by echocardiography. Results: Epicardial adipose tissue thicknesses of the children with FMF were found to be significantly greater than that of controls (5.1 +/- 1.4 vs. 4.5 +/- 0.9 mm, p = 0.036). FMF patients had significantly higher MPV values compared with the controls (7.8 +/- 1.1 vs. 7.3 +/- 1.4 fl, p = 0.044). Age at diagnosis, duration of delay in diagnosis, and MPV values were found to be correlated with EAT thickness in the patient group (r = 0.49, p = 0.001 for the former parameters and r = 0.32, p = 0.04 for MPV). Conclusion: Epicardial adipose tissue thickness and MPV values seem to be increased in children with FMF. These findings may indicate an increased risk of atherosclerosis in FMF patients.en_US
dc.identifier.doi10.1186/s13052-015-0120-z
dc.identifier.issn1720-8424
dc.identifier.issn1824-7288
dc.identifier.pmid25887962
dc.identifier.scopus2-s2.0-84924061922
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1186/s13052-015-0120-z
dc.identifier.urihttps://hdl.handle.net/11468/18256
dc.identifier.volume41en_US
dc.identifier.wosWOS:000350317100001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherBmcen_US
dc.relation.ispartofItalian Journal of Pediatrics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFamilial Mediterranean Feveren_US
dc.subjectEpicardial Adipose Tissue Thicknessen_US
dc.subjectMean Platelet Volumeen_US
dc.subjectAtherosclerosisen_US
dc.subjectInflammationen_US
dc.titleAssessment of epicardial adipose tissue thickness and the mean platelet volume in children with familial Mediterranean feveren_US
dc.titleAssessment of epicardial adipose tissue thickness and the mean platelet volume in children with familial Mediterranean fever
dc.typeArticleen_US

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