Intravesical oxybutynin affects bladder permeability
| dc.contributor.author | Ersay, Ahmet | |
| dc.contributor.author | Demirtaş, Ömer Can | |
| dc.date.accessioned | 2024-04-24T17:56:12Z | |
| dc.date.available | 2024-04-24T17:56:12Z | |
| dc.date.issued | 2001 | |
| dc.department | Dicle Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Üroloji Ana Bilim Dalı | en_US |
| dc.description.abstract | To investigate the effects of intravesical application of oxybutynin chloride on bladder permeability we designed an animal model. Female Guinea pigs were given 3 different test solutions; phosphate buffered saline (PBS), 50% acetone and 1.27 × 10-2 M oxybutynin chloride solution. Then 99mTc-DTPA 45 ?Ci in 2 ml normal saline was instilled into the bladder lumen in each animals and allowed to dwell for 30 minutes. At the end of exposure time, the net count data in each 1 ml serum sample were corrected for radioactive decay and converted to the total percentage of administered dose. 99mTc-DTPA absorption percentages of both acetone and oxybutynin groups were significantly higher than that of PBS group (mean 3.2 ± 2.9% p < 0.001). Intravesical oxybutynin application increases bladder permeability 5 times compared with PBS administration. This observation can also explain how rapid absorption of oxybutynin through the bladder into the systemic circulation occurs. | en_US |
| dc.identifier.citation | Ersay, A. ve Demirtaş, Ö. C. (2001). Intravesical oxybutynin affects bladder permeability. International Urology and Nephrology, 32(3), 359-361. | |
| dc.identifier.doi | 10.1023/A:1017595401988 | |
| dc.identifier.endpage | 361 | en_US |
| dc.identifier.issn | 0301-1623 | |
| dc.identifier.issue | 3 | en_US |
| dc.identifier.pmid | 11583352 | |
| dc.identifier.scopus | 2-s2.0-0034844778 | |
| dc.identifier.scopusquality | Q2 | |
| dc.identifier.startpage | 359 | en_US |
| dc.identifier.uri | https://doi.org/10.1023/A:1017595401988 | |
| dc.identifier.uri | https://hdl.handle.net/11468/23373 | |
| dc.identifier.uri | https://link.springer.com/article/10.1023/A:1017595401988 | |
| dc.identifier.volume | 32 | en_US |
| dc.indekslendigikaynak | Scopus | |
| dc.indekslendigikaynak | PubMed | |
| dc.language.iso | en | en_US |
| dc.relation.ispartof | International Urology and Nephrology | |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.subject | Administration | en_US |
| dc.subject | Bladder | en_US |
| dc.subject | Intravesical | en_US |
| dc.subject | Oxybutynin chloride | en_US |
| dc.title | Intravesical oxybutynin affects bladder permeability | en_US |
| dc.title | Intravesical oxybutynin affects bladder permeability | |
| dc.type | Article | en_US |
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