Intravesical oxybutynin affects bladder permeability
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Tarih
2001
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
To investigate the effects of intravesical application of oxybutynin chloride on bladder permeability we designed an animal model. Female Guinea pigs were given 3 different test solutions; phosphate buffered saline (PBS), 50% acetone and 1.27 × 10-2 M oxybutynin chloride solution. Then 99mTc-DTPA 45 ?Ci in 2 ml normal saline was instilled into the bladder lumen in each animals and allowed to dwell for 30 minutes. At the end of exposure time, the net count data in each 1 ml serum sample were corrected for radioactive decay and converted to the total percentage of administered dose. 99mTc-DTPA absorption percentages of both acetone and oxybutynin groups were significantly higher than that of PBS group (mean 3.2 ± 2.9% p < 0.001). Intravesical oxybutynin application increases bladder permeability 5 times compared with PBS administration. This observation can also explain how rapid absorption of oxybutynin through the bladder into the systemic circulation occurs.
Açıklama
Anahtar Kelimeler
Administration, Bladder, Intravesical, Oxybutynin chloride
Kaynak
International Urology and Nephrology
WoS Q Değeri
Scopus Q Değeri
Q2
Cilt
32
Sayı
3
Künye
Ersay, A. ve Demirtaş, Ö. C. (2001). Intravesical oxybutynin affects bladder permeability. International Urology and Nephrology, 32(3), 359-361.
