Comparison of Renoprotective Effect of Dabigatran With Low-Molecular-Weight Heparin

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dc.contributor.authorYazici, Suleyman
dc.contributor.authorKarahan, Oguz
dc.contributor.authorOral, Mehmet Kerem
dc.contributor.authorBayramoglu, Zehra
dc.contributor.authorUnal, Mehmet
dc.contributor.authorCaynak, Baris
dc.contributor.authorSagbas, Ertan
dc.date.accessioned2024-04-24T17:14:40Z
dc.date.available2024-04-24T17:14:40Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: The susceptibility of tissue to ischemia-reperfusion (I/R) injury is a major obstacle to tissue regeneration and cellular survival. In this study, we investigated the possible renoprotective effect of dabigatran in an experimental renal I/R model. Method: A total of 25 rats were randomly divided into 5 equal groups. The control group was used to obtain basal values of oxidant and antioxidant biomarkers. The sham group was used to obtain renal prolidase and malondialdehyde (MDA) levels after renal ischemia (for 45 minutes) and reperfusion (for 1 hour). A standard diet was followed. Oral 15 mg/kg dabigatran etexilate was administrated to group I, intraperitoneal 250 U/kg enoxaparin sodium was administrated to group II, and intraperitoneal 250 U/kg bemiparin sodium was administrated to group III for 1 week before the renal I/R was performed. Renal tissue samples were obtained during the first hour of reperfusion to detect renal prolidase and MDA levels in these groups, after which the rats were euthanized. Results: Renal prolidase levels were significantly higher in the sham group compared with the control group (1834.2 982.3 U/g protein vs 238.8 +/- 43.6U/g protein; P = .001). Lower prolidase levels were observed in groups II (838.7 +/- 123.8 U/g protein) and III (1012.9 +/- 302.3 U/g protein), and the lowest prolidase levels occurred in group I (533.8 +/- 96.2 U/g protein; P < .05) when compared with the sham group. The MDA levels were significantly lower (P < .05) in groups I, II, and III (163.9 +/- 41.5, 185.4 +/- 51.0, and 138.2 +/- 22.6 mol/g protein, respectively) compared with the sham group. Conclusion: Dabigatran etexilate, a univalent direct thrombin inhibitor, may protect the renal tissue more effectively when compared to low-molecular-weight heparins.en_US
dc.identifier.doi10.1177/1076029615571629
dc.identifier.endpage365en_US
dc.identifier.issn1076-0296
dc.identifier.issn1938-2723
dc.identifier.issue4en_US
dc.identifier.pmid25681331
dc.identifier.scopus2-s2.0-84962469210
dc.identifier.scopusqualityQ2
dc.identifier.startpage361en_US
dc.identifier.urihttps://doi.org/10.1177/1076029615571629
dc.identifier.urihttps://hdl.handle.net/11468/18126
dc.identifier.volume22en_US
dc.identifier.wosWOS:000373916700008
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofClinical and Applied Thrombosis-Hemostasis
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIschemia-Reperfusion Injuryen_US
dc.subjectOxidative Damageen_US
dc.subjectLmwhen_US
dc.subjectDabigatranen_US
dc.titleComparison of Renoprotective Effect of Dabigatran With Low-Molecular-Weight Heparinen_US
dc.titleComparison of Renoprotective Effect of Dabigatran With Low-Molecular-Weight Heparin
dc.typeArticleen_US

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