Altered lipid peroxidation markers are related to post-traumatic stress disorder (PTSD) and not trauma itself in earthquake survivors

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dc.contributor.authorAtli, Abdullah
dc.contributor.authorBulut, Mahmut
dc.contributor.authorBez, Yasin
dc.contributor.authorKaplan, Ibrahim
dc.contributor.authorOzdemir, Pinar Guzel
dc.contributor.authorUysal, Cem
dc.contributor.authorSelcuk, Hilal
dc.date.accessioned2024-04-24T16:01:53Z
dc.date.available2024-04-24T16:01:53Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe traumatic life events, including earthquakes, war, and interpersonal conflicts, cause a cascade of psychological and biological changes known as post-traumatic stress disorder (PTSD). Malondialdehyde (MDA) is a reliable marker of lipid peroxidation, and paraoxonase is a known antioxidant enzyme. The aims of this study were to investigate the relationship between earthquake trauma, PTSD effects on oxidative stress and the levels of serum paraoxonase 1 (PON1) enzyme activity, and levels of serum MDA. The study was carried out on three groups called: the PTSD group, the traumatized with earthquake exercise group, and healthy control group, which contained 32, 31, and 38 individuals, respectively. Serum MDA levels and PON1 enzyme activities from all participants were measured, and the results were compared across all groups. There were no significant differences between the PTSD patients and non-PTSD earthquake survivors in terms of the study variables. The mean PON1 enzyme activity from PTSD patients was significantly lower, while the mean MDA level was significantly higher than that of the healthy control group (p < 0.01 for both measurements). Similarly, earthquake survivors who did not develop PTSD showed higher MDA levels and lower PON1 activity when compared to healthy controls. However, the differences between these groups did not reach a statistically significant level. Increased MDA level and decreased PON1 activity measured in PTSD patients after earthquake and may suggest increased oxidative stress in these patients. The nonsignificant trends that are observed in lipid peroxidation markers of earthquake survivors may indicate higher impact of PTSD development on these markers than trauma itself. For example, PTSD diagnosis seems to add to the effect of trauma on serum MDA levels and PON1 enzyme activity. Thus, serum MDA levels and PON1 enzyme activity may serve as biochemical markers of PTSD diagnosis.en_US
dc.identifier.doi10.1007/s00406-015-0638-5
dc.identifier.endpage336en_US
dc.identifier.issn0940-1334
dc.identifier.issn1433-8491
dc.identifier.issue4en_US
dc.identifier.pmid26324882
dc.identifier.scopus2-s2.0-84940563321
dc.identifier.scopusqualityQ1
dc.identifier.startpage329en_US
dc.identifier.urihttps://doi.org/10.1007/s00406-015-0638-5
dc.identifier.urihttps://hdl.handle.net/11468/14454
dc.identifier.volume266en_US
dc.identifier.wosWOS:000376673400005
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofEuropean Archives of Psychiatry and Clinical Neuroscience
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPtsden_US
dc.subjectEarthquakeen_US
dc.subjectLipid Peroxidationen_US
dc.subjectBiological Markersen_US
dc.subjectOxidative Stressen_US
dc.titleAltered lipid peroxidation markers are related to post-traumatic stress disorder (PTSD) and not trauma itself in earthquake survivorsen_US
dc.titleAltered lipid peroxidation markers are related to post-traumatic stress disorder (PTSD) and not trauma itself in earthquake survivors
dc.typeArticleen_US

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