Hypothalamic-pituitary-gonadal axis hormones and cortisol in both menstrual phases of women with chronic fatigue syndrome and effect of depressive mood on these hormones

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dc.contributor.authorCevik, R
dc.contributor.authorGur, A
dc.contributor.authorAcar, S
dc.contributor.authorNas, K
dc.contributor.authorSarac, AJ
dc.date.accessioned2024-04-24T17:14:52Z
dc.date.available2024-04-24T17:14:52Z
dc.date.issued2004
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: Chronic fatigue syndrome (CFS) is a disease which defined as medically unexplained, disabling fatigue of 6 months or more duration and often accompanied by several of a long list of physical complaints. We aimed to investigate abnormalities of hypothalamic- pituitary-gonadal (HPG) axis hormones and cortisol concentrations in premenopausal women with CFS and find out effects of depression rate on these hormones. Methods: We examined follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol, progesterone and cortisol concentrations in 43 premenopausal women ( mean age: 32.86 +/- 7.11) with CFS and compared matched 35 healthy controls ( mean age: 31.14 +/- 6.19). Patients were divided according to menstrual cycle phases ( follicular and luteal) and compared with matched phase controls. Depression rate was assessed by Beck Depression Inventory (BDI), and patients with high BDI scores were compared to patients with low BDI scores. Results: There were no significant differences in FSH, LH, estradiol and progesterone levels in both of menstrual phases of patients versus controls. Cortisol levels were significantly lower in patients compared to controls. There were no significant differences in all hormone levels in patients with high depression scores versus patients with low depression scores. Conclusion: In spite of high depression rate, low cortisol concentration and normal HPG axis hormones of both menstrual phases are detected in premenopausal women with CFS. There is no differentiation between patients with high and low depression rate in all hormone levels. Depression condition of CFS may be different from classical depression and evaluation of HPG and HPA axis should be performed for understanding of pathophysiology of CFS and planning of treatment.en_US
dc.identifier.doi10.1186/1471-2474-5-47
dc.identifier.issn1471-2474
dc.identifier.pmid15588275
dc.identifier.scopus2-s2.0-12344256081
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1186/1471-2474-5-47
dc.identifier.urihttps://hdl.handle.net/11468/18233
dc.identifier.volume5en_US
dc.identifier.wosWOS:000226530300001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherBmcen_US
dc.relation.ispartofBmc Musculoskeletal Disorders
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject[No Keyword]en_US
dc.titleHypothalamic-pituitary-gonadal axis hormones and cortisol in both menstrual phases of women with chronic fatigue syndrome and effect of depressive mood on these hormonesen_US
dc.titleHypothalamic-pituitary-gonadal axis hormones and cortisol in both menstrual phases of women with chronic fatigue syndrome and effect of depressive mood on these hormones
dc.typeArticleen_US

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