The relationship of mast cell density in pulmonary, gastric and ovarian malignant epithelial tumors with tumor necrosis and vascularization

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dc.authorid0000-0002-2677-3971en_US
dc.contributor.authorKaya, Şeyhmus
dc.contributor.authorUçmak, Feyzullah
dc.contributor.authorBozdaǧ, Zübeyir
dc.contributor.authorFırat, Uǧur
dc.date.accessioned2021-07-30T06:00:37Z
dc.date.available2021-07-30T06:00:37Z
dc.date.issued2020en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıklar Ana Bilim Dalıen_US
dc.description.abstractAlthough many studies have been conducted to explore the relationship between mast cells (MC) and angiogenesis, comparison of this relationship with tumor necrosis has not been investigated to the best of our knowledge. Therefore, the relationship between MC and neovascularization in stomach, lung and ovarian malignant epithelial tumors (165 cases) in necrotizing or non-necrotizing cases was explored in this study. We immunohistochemically studied anti-mast cell tryptase antibody for MC and anti-CD34 antibody for vascular structures. MCs in the intra-tumoral and peritumoral fields, as well as vascular structures with luminal and monocellular appearances in the intratumoral field, were counted in each sample. Ten magnification fields were analyzed for each sample. In stomach and lung cases, the non-necrotizing group exhibited a greater number of MC and vascular structures in total. In ovarian cases, more MCs were counted overall in the necrotizing group, but there were fewer vascular structures. The increase in the number of MC and vascular structures in lungs and stomach in the non-necrotizing group supports the theory that MCs are involved in tumor progression. Necrosis, which can be induced on the basis of restricted neovascularization through inhibition of MCs in lung and stomach tumors, may be a treatment method.en_US
dc.identifier.citationKaya, Ş., Uçmak, F., Bozdaǧ, Z. ve Fırat, U. (2020). The relationship of mast cell density in pulmonary, gastric and ovarian malignant epithelial tumors with tumor necrosis and vascularization. Polish Journal of Pathology, 71(3), 221-228.en_US
dc.identifier.doi10.5114/pjp.2020.99788
dc.identifier.endpage228en_US
dc.identifier.issn1233-9687
dc.identifier.issue3en_US
dc.identifier.pmid33112112
dc.identifier.scopus2-s2.0-85094577527
dc.identifier.scopusqualityQ4
dc.identifier.startpage221en_US
dc.identifier.urihttps://www.termedia.pl/The-relationship-of-mast-cell-density-in-pulmonary-gastric-and-ovarian-malignant-epithelial-tumors-with-tumor-necrosis-and-vascularization,55,42022,0,1.html
dc.identifier.urihttps://hdl.handle.net/11468/7259
dc.identifier.volume71en_US
dc.identifier.wosWOS:000582396300004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorUçmak, Feyzullah
dc.institutionauthorBozdaǧ, Zübeyir
dc.institutionauthorFırat, Uǧur
dc.language.isoenen_US
dc.publisherTermedia Publishing House Ltd.en_US
dc.relation.ispartofPolish Journal of Pathology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMalignant epithelial tumoren_US
dc.subjectMast cellen_US
dc.subjectNecrosisen_US
dc.subjectVascularizationen_US
dc.titleThe relationship of mast cell density in pulmonary, gastric and ovarian malignant epithelial tumors with tumor necrosis and vascularizationen_US
dc.titleThe relationship of mast cell density in pulmonary, gastric and ovarian malignant epithelial tumors with tumor necrosis and vascularization
dc.typeArticleen_US

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