Evaluation of insulin sensitivity in hyperprolactinemic subjects by euglycemic hyperinsulinemic clamp technique

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dc.contributor.authorTuzcu, Alpaslan
dc.contributor.authorYalaki, Serkan
dc.contributor.authorArikan, Senay
dc.contributor.authorGokalp, Deniz
dc.contributor.authorBahcec, Mithat
dc.contributor.authorTuzcu, Sadiye
dc.date.accessioned2024-04-24T16:02:19Z
dc.date.available2024-04-24T16:02:19Z
dc.date.issued2009
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe background and aim of the study is to evaluate insulin sensitivity in hyperprolactinemic subjects via euglycemic hyperinsulinemic clamp technique. Sixteen hyperprolactinemic subjects and 12 healthy subjects were included in the study. HOMA-B and HOMA-IR values of groups were calculated. Euglycemic hyperinsulinemic clamp technique was performed in both groups, and the M value of the groups was defined. Mann-Whitney U and chi-square tests were used in statistical analysis. Basal insulin level of hyperprolactinemic patients were higher than the control group (6.85 +/- A 4.68; 3.66 +/- A 0.88 mu U/ml respectively; P < 0.05). Mean HOMA-IR and HOMA-B values of patients were higher than control group (1.49 +/- A 1.30; 0.78 +/- A 0.27 respectively; P = 0.02 and 136.28 +/- A 72.53; 64.77 +/- A 23.31, respectively, P < 0.001). M values of the patients were statistically lower than the control group (5.64 +/- A 2.36; 7.05 +/- A 1.62 kg/mg/min respectively; P < 0.05). (1) Hyperprolactinemic patients were more insulin resistant than control subjects. (2) Insulin resistance in hyperprolactinemic patients is not associated with obesity or anthropometric parameters such as fat content, waist circumference and BMI.en_US
dc.identifier.doi10.1007/s11102-009-0183-1
dc.identifier.endpage334en_US
dc.identifier.issn1386-341X
dc.identifier.issue4en_US
dc.identifier.pmid19408128
dc.identifier.scopus2-s2.0-70350294653
dc.identifier.scopusqualityQ2
dc.identifier.startpage330en_US
dc.identifier.urihttps://doi.org/10.1007/s11102-009-0183-1
dc.identifier.urihttps://hdl.handle.net/11468/14738
dc.identifier.volume12en_US
dc.identifier.wosWOS:000270977600008
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofPituitary
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHyperprolactinemiaen_US
dc.subjectInsulin Resistanceen_US
dc.subjectEuglycemic Clampen_US
dc.subjectHoma-Iren_US
dc.subjectHoma-Ben_US
dc.titleEvaluation of insulin sensitivity in hyperprolactinemic subjects by euglycemic hyperinsulinemic clamp techniqueen_US
dc.titleEvaluation of insulin sensitivity in hyperprolactinemic subjects by euglycemic hyperinsulinemic clamp technique
dc.typeArticleen_US

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