Angiotensin-converting enzyme gene insertion/deletion polymorphism with metabolic syndrome in Turkish patients

Basit Öğe Kaydı
dc.contributor.authorSimsek, S.
dc.contributor.authorTekes, S.
dc.contributor.authorTurkyilmaz, A.
dc.contributor.authorTuzcu, A. K.
dc.contributor.authorKilic, F.
dc.contributor.authorCulcu, N. N.
dc.contributor.authorIsik, B.
dc.date.accessioned2024-04-24T17:20:44Z
dc.date.available2024-04-24T17:20:44Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: The ACE gene has received substantial attention in recent years as candidate for a variety of diseases. The most common polymorphism in ACE gene is the Insertion/Deletion (I/D, rs4646994) polymorphism located on intron 16. Aim: We investigated the association between metabolic syndrome (MS) and the insertion (I) -deletion (D) polymorphisms in the angiotensin converting enzyme (ACE) gene in south-east of Turkey. Subjects and methods: One hundred and sixty subjects, with 101 cases of MS and 59 age-and gender-matched healthy controls were included in the study. Results: The frequency of ACE I/D polymorphism was found to be 49.5% for DD, 36.6% for ID, and 13.9% for II in the MSstudy group and 44.1% for DD, 42.4% for ID and 13.5% for II in the control group. Allele frequencies were found to be 0.68% for D and 0.32% for I allele in the study group with MS and 0.65% for D, 0.35% for I allele in the control group. The I/D polymorphism of the ACE gene, DD, ID, and II genotypes occurred with similar frequencies in the study group with MS and the control group with no significant differences (p > 0.05). On applying one-way analysis of variance to different ACE gene polymorphic groups in patients with MS were not significantly associated to ACE gene polymorphism and waist circumference, systolic blood pressure, diastolic blood pressure, fasting blood glucose, HDL, and LDL (p > 0.05). Conclusions: Further studies of patients in larger numbers and of different ethnic backgrounds may be necessary to elucidate the association between the ACE I/D gene polymorphism and MS.en_US
dc.identifier.doi10.3275/8967
dc.identifier.endpage863en_US
dc.identifier.issn0391-4097
dc.identifier.issn1720-8386
dc.identifier.issue10en_US
dc.identifier.pmid23685945
dc.identifier.scopus2-s2.0-84891720999
dc.identifier.scopusqualityQ1
dc.identifier.startpage860en_US
dc.identifier.urihttps://doi.org/10.3275/8967
dc.identifier.urihttps://hdl.handle.net/11468/19225
dc.identifier.volume36en_US
dc.identifier.wosWOS:000335149600012
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Endocrinological Investigation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAce I/D Polymorphismen_US
dc.subjectGene Polymorphismen_US
dc.subjectMetabolic Syndromeen_US
dc.titleAngiotensin-converting enzyme gene insertion/deletion polymorphism with metabolic syndrome in Turkish patientsen_US
dc.titleAngiotensin-converting enzyme gene insertion/deletion polymorphism with metabolic syndrome in Turkish patients
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu