Effects of fentanyl on pancreatic cancer cell proliferation and cancer stem cell differentiation

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dc.contributor.authorÇelik, Feyzi
dc.contributor.authorDuran, Tuğçe
dc.date.accessioned2021-09-28T05:56:48Z
dc.date.available2021-09-28T05:56:48Z
dc.date.issued2019en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Anesteziyoloji ve Reanimasyon Ana Bilim Dalıen_US
dc.descriptionPMID:31880513
dc.description.abstractPancreatic cancer is one of the most aggressive cancer due to the late diagnosis and failure to respond to the treatment despite advances in tumor biology and the development of new cancer therapeutic strategies. It has been reported that these characteristics of pancreatic cancer originate from cancer stem cells within the tumor mass. It has also been reported that Fentanyl is a fast-acting analgesic that binds to the mu-opioid receptors and some other mu-opioid receptors are involved in this cancer process. In this study, we determined the effect of Fentanyl on PANC-1 cells, by assessing the gene expression of cancer stem cell marker genes (Nanog, Oct4, and Sox2) and apoptosis-related genes (BAD, Bax, Bcl-2, and p53) by Quantitative RealTime PCR. The number of cancer stem cells was determined by Flow Cytometry. The results of our study showed that Fentanyl administration decreased the number of cancer and cancer stem cells in the PANC-1 cell population, decreased the gene expression of stem cell marker and increased the expression of apoptosis-related genes. These results indicate that Fentanyl, which is used routinely in the pain palliation of pancreatic cancer, can be considered as an option in the treatment of pancreatic cancer.en_US
dc.identifier.citationÇelik, F. ve Duran, T. (2019). Effects of fentanyl on pancreatic cancer cell proliferation and cancer stem cell differentiation. Cellular and Molecular Biology, 65(7), 21-25.en_US
dc.identifier.doi10.14715/cmb/2019.65.7.5
dc.identifier.endpage25en_US
dc.identifier.issn0145-5680
dc.identifier.issue7en_US
dc.identifier.pmid31880513
dc.identifier.scopus2-s2.0-85077285312
dc.identifier.scopusqualityQ4
dc.identifier.startpage21en_US
dc.identifier.urihttps://www.cellmolbiol.org/index.php/CMB/article/view/3125
dc.identifier.urihttps://hdl.handle.net/11468/7801
dc.identifier.volume65en_US
dc.identifier.wosWOS:000489886900005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÇelík, Feyzi
dc.language.isoenen_US
dc.publisherCellular and Molecular Biology Associationen_US
dc.relation.ispartofCellular and Molecular Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectApoptosisen_US
dc.subjectCancer stem cellen_US
dc.subjectFentanylen_US
dc.subjectPANC-1 cellen_US
dc.titleEffects of fentanyl on pancreatic cancer cell proliferation and cancer stem cell differentiationen_US
dc.titleEffects of fentanyl on pancreatic cancer cell proliferation and cancer stem cell differentiation
dc.typeArticleen_US

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