Assesment the role of oxidative stress and efficacy of caffeic acid phenethyl ester (CAPE) on neurotoxicity induced by isoniazid and ethambutol in a rat model

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dc.contributor.authorUzar, E.
dc.contributor.authorVarol, S.
dc.contributor.authorAcar, A.
dc.contributor.authorFirat, U.
dc.contributor.authorBasarslan, S. K.
dc.contributor.authorEvliyaoglu, O.
dc.contributor.authorYucel, Y.
dc.date.accessioned2024-04-24T17:33:15Z
dc.date.available2024-04-24T17:33:15Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractOBJECTIVE: The aim of this study were to investigate a role of oxidative stress and the therapeutic efficacy of caffeic acid phenethyl ester (CAPE) in the pathogenesis of neurotoxicity induced by isoniazid and etambutol in a rat model. MATERIALS AND METHODS: Male Sprague-Dawley rats were randomly divided into eight experimental groups: control, INH, ETM, INH+ETM, INH+CAPE, ETM+CAPE, INH+ETM+CAPE, and CAPE treatment group, with ten animals in each group. INH and ETM doses were given orally within tap water for 30 days. CAPE was administered into relevant groups intraperitoneally for 30 days. Brain tissue and sciatic nerve were removed for biochemical and histopathological investigation. RESULTS: In the INH, ETM, and INH+ETM groups, malondialdehyde (MDA) and total oxidant status (TOS) levels were significantly higher than those of the control group (p < 0.05). Also, in these groups, brain total antioxidant capacity (TAC) levels, and superoxide dismutase (SOD) and PON-1 activities were decreased compared with the control group (p < 0.05). By a CAPE supplement within INH and ETM groups, there was a significant decrease in MDA and TOS (p < 0.05). In addition to a significant increase in TAC levels, and SOD and PON-1 activities both in brain and sciatic nerve tissues (p < 0.05). CONCLUSIONS: CAPE may protect against INH- and ETM-induced neurotoxicity in rat brain and sciatic nerve.en_US
dc.identifier.endpage2959en_US
dc.identifier.issn1128-3602
dc.identifier.issue19en_US
dc.identifier.pmid25339492
dc.identifier.scopus2-s2.0-84941074407
dc.identifier.scopusqualityQ2
dc.identifier.startpage2953en_US
dc.identifier.urihttps://hdl.handle.net/11468/20566
dc.identifier.volume18en_US
dc.identifier.wosWOS:000352209800025
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIsoniaziden_US
dc.subjectEthambutolen_US
dc.subjectOxidative Stressen_US
dc.subjectCapeen_US
dc.subjectNeurotoxicityen_US
dc.titleAssesment the role of oxidative stress and efficacy of caffeic acid phenethyl ester (CAPE) on neurotoxicity induced by isoniazid and ethambutol in a rat modelen_US
dc.titleAssesment the role of oxidative stress and efficacy of caffeic acid phenethyl ester (CAPE) on neurotoxicity induced by isoniazid and ethambutol in a rat model
dc.typeArticleen_US

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