Is there any significance of lung cancer histology to compare the diagnostic accuracies of 18F-FDG-PET/CT and 99mTc-MDP BS for the detection of bone metastases in advanced NSCLC?

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dc.contributor.authorInal, Ali
dc.contributor.authorKaplan, Muhammed Ali
dc.contributor.authorKucukoner, Mehmet
dc.contributor.authorUrakci, Zuhat
dc.contributor.authorDostbil, Zeki
dc.contributor.authorKomek, Hail
dc.contributor.authorOnder, Hakan
dc.date.accessioned2024-04-24T17:24:56Z
dc.date.available2024-04-24T17:24:56Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractAim of the study: Bone scintigraphy (BS) and fluorine-18 deoxyglucose positron emission tomography computed tomography (18F-FDG-PET/CT) are widely used for the detection of bone involvement. The optimal imaging modality for the detection of bone metastases in histological subgroups of non-small cell lung cancer (NSCLC) remains ambiguous. The aim of this study was to compare the efficacy of 18F-FDG-PET/C and Tc-99m-methylene diphosphonate (Tc-99m-MDP) BS in the detection of bone metastases of patients in NSCLC. Specifically, we compared the diagnostic accuracies of these imaging techniques evaluating bone metastasis in histological subgroups of NSCLC. Material and methods: Fifty-three patients with advanced NSCLC, who had undergone both 18F-FDG-PET/CT and BS and were eventually diagnosed as having bone metastasis, were enrolled in this retrospective study. Results: The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of 18F-FDG-PET/CT and BS were 90.4%, 99.4%, 98.1%, 96.6%, 97.0% and 84.6%, 93.1%, 82.5%, 93.2, 90.8%, respectively. The. statistics were calculated for 18F-FDG-PET/CT and BS. The kappa-value was 0.67 between 18F-FDG-PET/CT and BS in all patients. On the other hand, the kappa-value was 0.65 in adenocarcinoma, and 0.61 in squamous cell carcinoma between 18F-FDG-PET/CT and BS. The kappa-values suggested excellent agreement between all patients and histological subgroups of NSCLC. Conclusions: 18F-FDG-PET/CT was more favorable than BS in the screening of metastatic bone lesions, but the trend did not reach statistical significance in all patients and histological subgroups of NSCLC. Our results need to be validated in prospective and larger study clinical trials to further clarify this topic.en_US
dc.identifier.doi10.5114/wo.2014.42725
dc.identifier.endpage110en_US
dc.identifier.issn1428-2526
dc.identifier.issn1897-4309
dc.identifier.issue2en_US
dc.identifier.pmid24966793
dc.identifier.scopus2-s2.0-84902478836
dc.identifier.scopusqualityQ2
dc.identifier.startpage106en_US
dc.identifier.urihttps://doi.org/10.5114/wo.2014.42725
dc.identifier.urihttps://hdl.handle.net/11468/19884
dc.identifier.volume18en_US
dc.identifier.wosWOS:000422071800006
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTermedia Publishing House Ltden_US
dc.relation.ispartofWspolczesna Onkologia-Contemporary Oncology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject18f-Fdg-Pet/Cten_US
dc.subjectTc-99m-Methylene Diphosphonate Bone Scintigraphyen_US
dc.subjectBone Metastasesen_US
dc.subjectNon-Small Cell Lung Canceren_US
dc.titleIs there any significance of lung cancer histology to compare the diagnostic accuracies of 18F-FDG-PET/CT and 99mTc-MDP BS for the detection of bone metastases in advanced NSCLC?en_US
dc.titleIs there any significance of lung cancer histology to compare the diagnostic accuracies of 18F-FDG-PET/CT and 99mTc-MDP BS for the detection of bone metastases in advanced NSCLC?
dc.typeArticleen_US

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