Levels of proinflammatory cytokines and hs-CRP in patients with homozygous familial hypercholesterolaemia

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dc.contributor.authorGokalp, Deniz
dc.contributor.authorTuzcu, Alpaslan
dc.contributor.authorBahceci, Mithat
dc.contributor.authorArikan, Senay
dc.contributor.authorPirinccioglu, Ayfer Gozu
dc.contributor.authorBahceci, Selen
dc.date.accessioned2024-04-24T17:18:25Z
dc.date.available2024-04-24T17:18:25Z
dc.date.issued2009
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective - Homozygous familial hypercholesterolemia (FH) is an extremely rare (1/1.000.000) condition characterized by markedly increased LDL cholesterol levels and a significantly increased risk of premature coronary heart disease (CHD). We aimed to evaluate the levels of high-sensitivity C-reactive protein (hs-CRP) and proinflammatory cytokines, which are known to be associated with atherogenesis, in patients with this condition. Method and results - A total of 10 patients with homozygous FH (5 women and 5 men, mean age 17.0 +/- 6.9 years, body mass index (BMI) (18.8 +/- 1.9 kg/m(2)) and 16 healthy controls were included. hs-CRP levels, proinflammatory cytokine levels and lipid parameters were measured and compared between patients and control subjects. Homozygous FH patients had significantly higher total cholesterol, LDL-cholesterol and Lp(a) levels and significantly lower triglycericle and HDL cholesterol levels, compared to controls (P = 0.0001, for all). Serum hs-CRP (3.7 +/- 1.3 mg/L vs. 0.6 +/- 0.6 mg/L) and IL-1 beta, IL-2R, IL-6, IL-8, IL- 10, TNF-alpha levels were all significantly higher in the homozygous FH group, compared to controls (P = 0.0001, for all). Conclusions - Homozygous FH patients have significantly higher levels of hs-CRP and circulating proinflammatory cytokines, which may explain their increased risk of atherosclerotic disease. hs-CRP is an important biomarker that may be helpful in the identification of asymptomatic CHD in FH patients.en_US
dc.identifier.doi10.2143/AC.64.5.2042689
dc.identifier.endpage609en_US
dc.identifier.issn0001-5385
dc.identifier.issn1784-973X
dc.identifier.issue5en_US
dc.identifier.pmid20058505
dc.identifier.scopus2-s2.0-75749096989
dc.identifier.scopusqualityQ3
dc.identifier.startpage603en_US
dc.identifier.urihttps://doi.org/10.2143/AC.64.5.2042689
dc.identifier.urihttps://hdl.handle.net/11468/18775
dc.identifier.volume64en_US
dc.identifier.wosWOS:000272183700005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherActa Cardiologicaen_US
dc.relation.ispartofActa Cardiologica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectProinflammatory Cytokinesen_US
dc.subjectHs-Crpen_US
dc.subjectHomozygous Familial Hypercholesterolaemiaen_US
dc.titleLevels of proinflammatory cytokines and hs-CRP in patients with homozygous familial hypercholesterolaemiaen_US
dc.titleLevels of proinflammatory cytokines and hs-CRP in patients with homozygous familial hypercholesterolaemia
dc.typeArticleen_US

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