Retina ganglion cell/inner plexiform layer and peripapillary nerve fiber layer thickness in patients with acromegaly

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dc.contributor.authorSahin, Muhammed
dc.contributor.authorSahin, Alparslan
dc.contributor.authorKilinc, Faruk
dc.contributor.authorYuksel, Harun
dc.contributor.authorOzkurt, Zeynep Gursel
dc.contributor.authorTurkcu, Fatih Mehmet
dc.contributor.authorPekkolay, Zafer
dc.date.accessioned2024-04-24T16:02:11Z
dc.date.available2024-04-24T16:02:11Z
dc.date.issued2017
dc.departmentDicle Üniversitesien_US
dc.description.abstractIncreased secretion of growth hormone and insulin-like growth factor-1 in acromegaly has various effects on multiple organs. However, the ocular effects of acromegaly have yet to be investigated in detail. The aim of the present study was to compare retina ganglion cell/inner plexiform layer (GCIPL) and peripapillary nerve fiber layer thickness (pRNFL) between patients with acromegaly and healthy control subjects using spectral domain optical coherence tomography (SD-OCT). This cross-sectional, comparative study included 18 patients with acromegaly and 20 control subjects. All participants underwent SD-OCT to measure pRNFL (in the seven peripapillary areas), GCIPL (in the nine ETDRS areas), and central macular thickness (CMT). Visual field (VF) examinations were performed using a Humphrey field analyzer in acromegalic patients. Measurements were compared between patients with acromegaly and control subjects. A total of 33 eyes of 18 patients with acromegaly and 40 eyes of 20 control subjects met the inclusion criteria of the present study. The overall calculated average pRNFL thickness was significantly lower in patients with acromegaly than in control subjects (P = 0.01), with pRNFL thickness significantly lower in the temporal superior and temporal inferior quadrants. Contrary to our expectations, pRNFL thickness in the nasal quadrant was similar between acromegalic and control subjects. The mean overall pRNFL thickness and superonasal, nasal, inferonasal, and inferotemporal quadrant pRNFL thicknesses were found to correlate with the mean deviation (MD) according to Spearman's correlation. However, other quadrants were not correlated with VF sensitivity. No significant difference in CMT values was observed (P = 0.6). GCIPL thickness was significantly lower in all quadrants of the inner and outer macula, except for central and inferior outer quadrants, in the acromegaly group than that in the control group (P < 0.05). GCIPL thicknesses of the inferior inner and outer macula quadrants were found to correlate with MD, whereas no correlation was observed between other quadrants and VF sensitivity. We demonstrated that GCIPL thickness decreased in patients with acromegaly compared with that in control subjects. However, the nasal quadrant pRNFL thickness was similar in acromegaly, in contrast to our expectations. SD-OCT may have utility in the assessment of the effects of acromegaly on retinal structures.en_US
dc.identifier.doi10.1007/s10792-016-0310-8
dc.identifier.endpage598en_US
dc.identifier.issn0165-5701
dc.identifier.issn1573-2630
dc.identifier.issue3en_US
dc.identifier.pmid27492731
dc.identifier.scopus2-s2.0-84983001909
dc.identifier.scopusqualityQ2
dc.identifier.startpage591en_US
dc.identifier.urihttps://doi.org/10.1007/s10792-016-0310-8
dc.identifier.urihttps://hdl.handle.net/11468/14678
dc.identifier.volume37en_US
dc.identifier.wosWOS:000401918500021
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofInternational Ophthalmology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcromegalyen_US
dc.subjectCentral Macular Thicknessen_US
dc.subjectMacular Ganglion Cell Layer/Inner Plexiform Layeren_US
dc.subjectPeripapillary Retinal Nerve Fiber Layeren_US
dc.titleRetina ganglion cell/inner plexiform layer and peripapillary nerve fiber layer thickness in patients with acromegalyen_US
dc.titleRetina ganglion cell/inner plexiform layer and peripapillary nerve fiber layer thickness in patients with acromegaly
dc.typeArticleen_US

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